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Rios, F. J. et al. (2020) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, 116(3), pp. 721-735. (doi: 10.1093/cvr/cvz164) (PMID:31250885) (PMCID:PMC7252442)

Arendse, L. B., Danser, A. H. J., Poglitsch, M., Touyz, R. M. , Burnett Jr, J. C., Llorens-Cortes, C., Ehlers, M. R. and Sturrock, E. D. (2019) Novel therapeutic approaches targeting the renin angiotensin system and associated peptides in hypertension and heart failure. Pharmacological Reviews, 71(4), pp. 539-570. (doi: 10.1124/pr.118.017129) (PMID:31537750) (PMCID:PMC6782023)

Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and De Lucca Camargo, L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi: 10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)

Alves-Lopes, R., Neves, K. B. and Touyz, R. M. (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi: 10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., Belin de Chantemele, E. J., Tostes, R. C. and Touyz, R. M. (2019) Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sciences, 221, pp. 29-34. (doi: 10.1016/j.lfs.2019.01.043) (PMID:30721707) (PMCID:PMC6686670)

Touyz, R. M. and De Lucca Camargo, L. (2019) Microglia, the missing link in the brain-gut-hypertension axis. Circulation Research, 124(5), pp. 671-673. (doi: 10.1161/CIRCRESAHA.119.314718) (PMID:30817265)

Touyz, R. M. , Anagnostopoulou, A., De Lucca Camargo, L. , Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi: 10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)

Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)

Dobbin, S. J.H. , Cameron, A. C., Petrie, M. C. , Jones, R. J. , Touyz, R. M. and Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104(24), pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726) (PMID:30228246) (PMCID:PMC6268130)

Alves-Lopes, R. and Touyz, R. M. (2018) PARP-1 (poly[ADP-ribose] polymerase-1): a novel target in aortic aneurysm. Hypertension, 72(5), pp. 1087-1089. (doi: 10.1161/HYPERTENSIONAHA.118.11830) (PMID:30354832) (PMCID:PMC6218001)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Touyz, R. M. , Herrmann, S. M.S. and Herrmann, J. (2018) Vascular toxicities with VEGF inhibitor therapies-focus on hypertension and arterial thrombotic events. Journal of the American Society of Hypertension, 12(6), pp. 409-425. (doi: 10.1016/j.jash.2018.03.008) (PMID:29703600) (PMCID:PMC6168784)

Touyz, R. M. and Herrmann, J. (2018) Cardiotoxicity with vascular endothelial growth factor inhibitor therapy. npj Precision Oncology, 2(1), 13. (doi: 10.1038/s41698-018-0056-z)

Petrie, J. R. , Guzik, T. J. and Touyz, R. M. (2018) Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Canadian Journal of Cardiology, 34(5), pp. 575-584. (doi: 10.1016/j.cjca.2017.12.005) (PMID:29459239) (PMCID:PMC5953551)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Nguyen Dinh Cat, A. et al. (2018) Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling. Scientific Reports, 8, 2952. (doi: 10.1038/s41598-018-21087-5) (PMID:29440699) (PMCID:PMC5811612)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi: 10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2018) Aldosterone, SGK1, and ion channels in the kidney. Clinical Science, 132(2), pp. 173-183. (doi: 10.1042/CS20171525) (PMID:29352074) (PMCID:PMC5817097)

Touyz, R. M. and Montezano, A. C. (2018) Angiotensin-(1–7) and vascular function: the clinical context. Hypertension, 71(1), pp. 68-69. (doi: 10.1161/HYPERTENSIONAHA.117.10406) (PMID:29203630)

Savoia, C., Volpe, M., Grassi, G., Borghi, C., Rosei, E. A. and Touyz, R. M. (2017) Personalized medicine—a modern approach for the diagnosis and management of hypertension. Clinical Science, 131(22), pp. 2671-2685. (doi: 10.1042/CS20160407) (PMID:29109301) (PMCID:PMC5736921)

Zhang, K., Zhang, Y., Feng, W., Chen, R., Chen, J., Touyz, R. M. , Wang, J. and Huang, H. (2017) Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), pp. 1933-1943. (doi: 10.1161/ATVBAHA.117.309161) (PMID:28860220)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2017) Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells. Biochimica et Biophysica Acta: General Subjects, 1861(8), pp. 2007-2019. (doi: 10.1016/j.bbagen.2017.05.004) (PMID:28483640) (PMCID:PMC5482324)

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi: 10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)

Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi: 10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)

Friederich-Persson, M., Nguyen Dinh Cat, A., Persson, P., Montezano, A. C. and Touyz, R. M. (2017) Brown adipose tissue regulates small artery function through NADPH oxidase 4-derived hydrogen peroxide and redox-sensitive protein kinase G-1α. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(3), pp. 455-465. (doi: 10.1161/atvbaha.116.308659) (PMID:28062507)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Yogi, A., Savoia, C. and Touyz, R. M. (2016) c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension. Hypertension, 68(5), pp. 1179-1190. (doi: 10.1161/HYPERTENSIONAHA.116.07699) (PMID:27620391)

Callera, G. et al. (2016) Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas. Bioscience Reports, 36(5), e00398. (doi: 10.1042/BSR20160344) (PMID:27612496) (PMCID:PMC5091470)

Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

Bruder-Nascimento, T. et al. (2016) Renoprotective effects of atorvastatin in diabetic mice: downregulation of RhoA and upregulation of Akt/GSK3. PLoS ONE, 11(9), e0162731. (doi: 10.1371/journal.pone.0162731) (PMID:27649495) (PMCID:PMC5029810)

Valinsky, W. C., Jolly, A., Miquel, P., Touyz, R. M. and Shrier, A. (2016) Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7). Journal of Biological Chemistry, 291(38), pp. 20163-20172. (doi: 10.1074/jbc.M116.735175) (PMID:27466368) (PMCID:PMC5025699)

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi: 10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)

Griendling, K. K., Touyz, R. M. , Zweier, J. L., Dikalov, S., Chilian, W., Yeong-Renn, C., Harrison, D. G. and Bhatnagar, A. (2016) Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American heart association. Circulation Research, 119(5), e39-e75. (doi: 10.1161/RES.0000000000000110) (PMID:27418630) (PMCID:PMC5446086)

Weber, M. A., Poulter, N. R., Schutte, A. E., Burrell, L. M., Horiuchi, M., Prabhakaran, D., Ramirez, A. J., Wang, J.-G., Schiffrin, E. L. and Touyz, R. (2016) Is it time to reappraise blood pressure thresholds and targets? Statement from the international society of hypertension - a global perspective. Hypertension, 68(2), pp. 266-268. (doi: 10.1161/HYPERTENSIONAHA.116.07818) (PMID:27354426)

Touyz, R. (2016) Lower is better in hypertension, but how low should blood pressure be targeted? Journal of the American Society of Hypertension, 10(8), pp. 621-622. (doi: 10.1016/j.jash.2016.06.028) (PMID:27436128) (PMCID:PMC4990139)

Nguyen Dinh Cat, A. et al. (2016) Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction: role of redox-sensitive PKG-1 and Rho kinase. Diabetes, 65(8), pp. 2392-2403. (doi: 10.2337/db15-1627) (PMID:27207514)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi: 10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., De Lucca Camargo, L. , Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi: 10.1124/jpet.115.230748) (PMID:26941168)

Touyz, R. M. and Dominiczak, A. F. (2016) Hypertension guidelines: is it time to reappraise blood pressure thresholds and targets? Hypertension, 67(4), pp. 688-689. (doi: 10.1161/hypertensionaha.116.07090) (PMID:26962205)

Antunes, T. T., Callera, G. E., He, Y., Yogi, A., Ryazanov, A. G., Ryazanov, L. V., Zhai, A., Stewart, D. J., Shrier, A. and Touyz, R. (2016) Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension. Hypertension, 67, pp. 763-773. (doi: 10.1161/HYPERTENSIONAHA.115.07021) (PMID:26928801) (PMCID:PMC4786473)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi: 10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Touyz, R. (2016) Protecting the heart in obesity: role of ACE2 and Its partners. Diabetes, 65(1), pp. 19-21. (doi: 10.2337/dbi15-0014) (PMID:26696636)

Burger, D., Turner, M., Munkonda, M. N. and Touyz, R. M. (2016) Endothelial microparticle-derived reactive oxygen species: role in endothelial signaling and vascular function. Oxidative Medicine and Cellular Longevity, 2016, 5047954. (doi: 10.1155/2016/5047954) (PMID:27313830) (PMCID:PMC4893592)

Cameron, A. C., Touyz, R. M. and Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32(7), pp. 852-862. (doi: 10.1016/j.cjca.2015.12.023) (PMID:26968393) (PMCID:PMC4989034)

Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)

Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi: 10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)

Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., De Lucca Camargo, L. and Touyz, R. M. (2015) Redox signaling, Nox5 and vascular remodeling in hypertension. Current Opinion in Nephrology and Hypertension, 24(5), pp. 425-433. (doi: 10.1097/MNH.0000000000000153) (PMID:26197203) (PMCID:PMC4727501)

Harvey, A., Montezano, A. C. and Touyz, R. M. (2015) Vascular biology of ageing—implications in hypertension. Journal of Molecular and Cellular Cardiology, 83, pp. 112-121. (doi: 10.1016/j.yjmcc.2015.04.011) (PMID:25896391) (PMCID:PMC4534766)

Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi: 10.1124/jpet.114.221002) (PMID:25617244)

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T., de Cassia Tostes, R., Touyz, R. M. and , (2013) Atorvastatin Inhibits Src/ROS-mediated Redox Sensitive And Pro-Inflammatory Actions of Aldosterone in Vascular Smooth Muscle Cells: Focus on Statins Pleiotropic Effects. Hypertension, 62(3 Sup), A488.

This list was generated on Mon Feb 26 15:16:33 2024 GMT.