Cameron, A. C., Touyz, R. M. and Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32(7), pp. 852-862. (doi: 10.1016/j.cjca.2015.12.023) (PMID:26968393) (PMCID:PMC4989034)
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Abstract
Development of new anticancer drugs has resulted in improved mortality rates and 5-year survival rates in patients with cancer. However, many of the modern chemotherapies are associated with cardiovascular toxicities that increase cardiovascular risk in cancer patients, including hypertension, thrombosis, heart failure, cardiomyopathy, and arrhythmias. These limitations restrict treatment options and might negatively affect the management of cancer. The cardiotoxic effects of older chemotherapeutic drugs such as alkylating agents, antimetabolites, and anticancer antibiotics have been known for a while. The newer agents, such as the antiangiogenic drugs that inhibit vascular endothelial growth factor signalling are also associated with cardiovascular pathology, especially hypertension, thromboembolism, myocardial infarction, and proteinuria. Exact mechanisms by which vascular endothelial growth factor inhibitors cause these complications are unclear but impaired endothelial function, vascular and renal damage, oxidative stress, and thrombosis might be important. With increasing use of modern chemotherapies and prolonged survival of cancer patients, the incidence of cardiovascular disease in this patient population will continue to increase. Accordingly, careful assessment and management of cardiovascular risk factors in cancer patients by oncologists and cardiologists working together is essential for optimal care so that prolonged cancer survival is not at the expense of increased cardiovascular events.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cameron, Dr Alan and Touyz, Professor Rhian and Lang, Professor Ninian |
| Authors: | Cameron, A. C., Touyz, R. M., and Lang, N. N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Canadian Journal of Cardiology |
| Publisher: | Pulsus Group Inc |
| ISSN: | 0828-282X |
| ISSN (Online): | 1916-7075 |
| Published Online: | 28 December 2015 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Canadian Journal of Cardiology 32(7):852-862 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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