Soil-transmitted helminth infections

Jourdan, P. M., Lamberton, P. H.L. , Fenwick, A. and Addiss, D. G. (2018) Soil-transmitted helminth infections. Lancet, 391(10117), pp. 252-265. (doi: 10.1016/S0140-6736(17)31930-X) (PMID:28882382)

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More than a quarter of the world's population is at risk of infection with the soil-transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura, and Strongyloides stercoralis. Infected children and adults present with a range of medical and surgical conditions, and clinicians should consider the possibility of infection in individuals living in, or returning from, endemic regions. Although safe and effective drugs are donated free to endemic countries, only half of at-risk children received treatment in 2016. This Seminar describes the epidemiology, lifecycles, pathophysiology, clinical diagnosis, management, and public health control of soil-transmitted helminths. Previous work has questioned the effect of population-level deworming; however, it remains beyond doubt that treatment reduces the severe consequences of soil-transmitted helminthiasis. We highlight the need for refined diagnostic tools and effective control options to scale up public health interventions and improve clinical detection and management of these infections.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lamberton, Professor Poppy
Authors: Jourdan, P. M., Lamberton, P. H.L., Fenwick, A., and Addiss, D. G.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Lancet
ISSN (Online):1474-547X
Published Online:04 September 2017
Copyright Holders:Copyright © 2017 Elsevier Ltd.
First Published:First published in Lancet 391(10117):252-265

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
730161SCHISTO-PERSISTPoppy LambertonEuropean Research Council (ERC)680088RI BIODIVERSITY ANIMAL HEALTH & COMPMED
623593Institutional Strategic Support Fund (ISSF)Anna DominiczakWellcome Trust (WELLCOTR)105614/Z/14/ZRI CARDIOVASCULAR & MEDICAL SCIENCES