Chevalier, F. D., Le Clec'h, W., Berriman, M. and Anderson, T. J.C. (2024) A single locus determines praziquantel response in Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 68(3), e01432-23. (doi: 10.1128/aac.01432-23) (PMID:38289079) (PMCID:PMC10916369)
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Abstract
We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.
| Item Type: | Articles |
|---|---|
| Additional Information: | This research was supported by a Cowles fellowship (W.L.C.) from Texas Biomedical Research Institute (13-1328.021) and NIH R01AI133749 (T.J.C.A.) and was conducted in facilities constructed with support from Research Facilities Improvement Program grant C06 RR013556 from the National Center for Research Resources. SNPRC research at Texas Biomedical Research Institute is supported by grant P51 OD011133 from the 570 Officeof Research Infrastructure Programs, NIH. Data availability: Sequence data is available from: PRJNA699326, PRJNA701978, PRJNA704646.Code is available on Zenodo (DOIs: 10.5281/zenodo.10407184 and 10.5281/zenodo.10407187 |
| Keywords: | drug resistance, genetic mapping, schistosome |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Berriman, Professor Matt |
| Creator Roles: | |
| Authors: | Chevalier, F. D., Le Clec'h, W., Berriman, M., and Anderson, T. J.C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Antimicrobial Agents and Chemotherapy |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| ISSN (Online): | 1098-6596 |
| Published Online: | 30 January 2024 |
| Copyright Holders: | Copyright: © 2024 Chevalier et al. |
| First Published: | First published in Antimicrobial Agents and Chemotherapy 68(3):e0143223 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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