The human Papillomavirus late life cycle and links to keratinocyte differentiation

Kirk, A. and Graham, S. (2024) The human Papillomavirus late life cycle and links to keratinocyte differentiation. Journal of Medical Virology, 96(2), e29461. (doi: 10.1002/jmv.29461) (PMID:38345171)

Abstract

Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the upper layers of the epithelium where the virus capsid proteins are synthesized. As these proteins are highly immunogenic, and the upper epithelium is an immune-privileged site, this spatial restriction aids immune evasion. Many decades of work have contributed to the current understanding of how this restriction occurs at a molecular level. This review will examine what is known about late gene expression in HPV-infected lesions and will dissect the intricacies of late gene regulation. Future directions for novel antiviral approaches will be highlighted.

• Item Type: Articles
• Additional Information: We acknowledge support from the Medical Research Council (MC_UU_12014) as core funding for the MRC University of Glasgow Centre for Virus Research and a studentship award to AK. Work in the Graham laboratory is funded by a Medical Research Council Confidence in Concept Award (MC_PC_19039) and awards from the Chief Scientist Office, Scotland (TCS/19/11 and TCS/22/24).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Graham, Professor Sheila and Kirk, Miss Anna
• Authors: Kirk, A., and Graham, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Journal of Medical Virology
• Publisher: Wiley
• ISSN: 0146-6615
• ISSN (Online): 1096-9071
• Copyright Holders: Copyright: © 2024 The Authors
• First Published: First published in Journal of Medical Virology 96(2): e29461
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
318605		Risk stratification of HPV in self taken vaginal samples - a potential molecular solution to screening	Sheila Graham	Office of the Chief Scientific Adviser (CSO)	TCS/22/24	SII - Virology
311038		Confidence in Concept 2020	Anna Dominiczak	Medical Research Council (MRC)	MC_PC_19039	MVLS - College Senior Management
315250		MRC PE seed funding - John McLauchlan	John McLauchlan	Medical Research Council (MRC)	MC_UU_12014	SII - Virology