Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
315332.pdf - Published Version Available under License Creative Commons Attribution. 2MB |
Abstract
The malaria parasite Plasmodium vivax remains a major global public health challenge, and no vaccine is approved for use in humans. Here, we assessed whether P. vivax strain-transcendent immunity can be achieved by repeated infection in Aotus monkeys. Sterile immunity was achieved after two homologous infections, whereas subsequent heterologous challenge provided only partial protection. IgG levels based on P. vivax lysate ELISA and protein microarray increased with repeated infections and correlated with the level of homologous protection. Parasite transcriptional profiles provided no evidence of major antigenic switching upon homologous or heterologous challenge. However, we observed significant sequence diversity and transcriptional differences in the P. vivax core gene repertoire between the two strains used in the study, suggesting that partial protection upon heterologous challenge is due to molecular differences between strains rather than immune evasion by antigenic switching. Our study demonstrates that sterile immunity against P. vivax can be achieved by repeated homologous blood stage infection in Aotus monkeys, thus providing a benchmark to test the efficacy of candidate blood stage P. vivax malaria vaccines.
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding for this study was provided in part by core funds from the Gorgas Memorial Institute of Health Studies and the Sistema Nacional de Investigación de Panamá, SENACYT-SNI awarded to N.O., Panamá, Panamá. This work was also supported by Wolfson Merit Royal Society Award (to M.M.) and Wellcome Trust Center Award 104111 (to F.A., J.L.S.F., T.D.O. and M.M.). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Obaldia, Dr Nicanor and Achcar, Dr Fiona and Otto, Professor Thomas and Marti, Professor Matthias and Da Silva Filho, Dr Joao |
| Authors: | Obaldia III, N., Da Silva Filho, J. L., Núñez, M., Glass, K. A., Oulton, T., Achcar, F., Wirjanata, G., Duraisingh, M., Felgner, P., Tetteh, K. K.A., Bozdech, Z., Otto, T. D., and Marti, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Life Science Alliance |
| Publisher: | Life Science Alliance |
| ISSN: | 2575-1077 |
| ISSN (Online): | 2575-1077 |
| Published Online: | 29 December 2023 |
| Copyright Holders: | Copyright © TheAuthor(s) 2023 |
| First Published: | First published in Life Science Alliance 7(3):e202302524 |
| Publisher Policy: | Reproduced under a creative commons licence |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information