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Faria, J., Briggs, E. M., Black, J. A. and McCulloch, R. (2022) Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome. Current Opinion in Microbiology, 70, 102209. (doi: 10.1016/j.mib.2022.102209)

Hu, C. , Annese, V. F. , Giagkoulovits, C. , Barrett, M. P. and Cumming, D. R. S. (2022) Factor VIII companion diagnostic for haemophilia. Frontiers in Bioengineering and Biotechnology, 10, 1006600. (doi: 10.3389/fbioe.2022.1006600) (PMCID:PMC9579283)

Chauché, C. , Rasid, O., Donachie, A. M., McManus, C. M., Löser, S., Campion, T., Richards, J., Smyth, D. J. , McSorley, H. J. and Maizels, R. M. (2022) Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β. Immunology, 167(2), pp. 197-211. (doi: 10.1111/imm.13528) (PMID:35758054)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

Sanchez, C. P., Manson, E. D. T., Moliner Cubel, S., Mandel, L., Weidt, S. K., Barrett, M. P. and Lanzer, M. (2022) The knock-down of the chloroquine resistance transporter PfCRT is linked to oligopeptide handling in Plasmodium falciparum. Microbiology Spectrum, 10(4), e0110122. (doi: 10.1128/spectrum.01101-22) (PMID:35867395) (PMCID:PMC9431119)

Varyani, F. et al. (2022) The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF). Mucosal Immunology, 15(6), pp. 1243-1256. (doi: 10.1038/s41385-022-00496-w) (PMID:35288645)

Webster, H. C., Gamino, V., Andrusaite, A. T., Ridgewell, O., McCowan, J., Shergold, A. L., Heieis, G. A., Milling, S. W.F. , Maizels, R. M. and Perona-Wright, G. (2022) Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response. Mucosal Immunology, 15(6), pp. 1257-1269. (doi: 10.1038/s41385-022-00513-y) (PMID:35428872)

Mukundan, A., Byeon, C.-H., Hinck, C. S., Cunningham, K., Campion, T., Smyth, D. J. , Maizels, R. M. and Hinck, A. P. (2022) Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-ß to its receptors, TßRI and TßRII. Journal of Biological Chemistry, 298(6), 101994. (doi: 10.1016/j.jbc.2022.101994) (PMID:35500648) (PMCID:PMC9163516)

Lindholm, H. T., Parmar, N., Drurey, C. , Campillo Poveda, M. , Vornewald, P. M., Ostrop, J., Díez-Sanchez, A., Maizels, R. M. and Oudhoff, M. J. (2022) BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia. Science Immunology, 7(71), eabl6543. (doi: 10.1126/sciimmunol.abl6543) (PMID:35559665)

Maizels, R. M. (2022) Ascarosides from helminths pack a punch against allergy. Proceedings of the National Academy of Sciences of the United States of America, 119(14), e2202250119. (doi: 10.1073/pnas.2202250119) (PMID:35353624) (PMCID:PMC9169083)

Pancheva, A., Wheadon, H. , Rogers, S. and Otto, T. D. (2022) Using topic modeling to detect cellular crosstalk in scRNA-seq. PLoS Computational Biology, 18(4), e1009975. (doi: 10.1371/journal.pcbi.1009975) (PMID:35395014)

Obaldía, N., Barahona, I., Lasso, J., Avila, M., Quijada, M., Nuñez, M. and Marti, M. (2022) Comparison of PvLAP5 and Pvs25 qRT-PCR assays for the detection of Plasmodium vivax gametocytes in field samples preserved at ambient temperature from remote malaria endemic regions of Panama. PLoS Neglected Tropical Diseases, 16(4), e0010327. (doi: 10.1371/journal.pntd.0010327) (PMID:35394999) (PMCID:PMC9020738)

MacKenzie, G., Jensen, R. W., Lavstsen, T. and Otto, T. D. (2022) Varia: a tool for prediction, analysis and visualisation of variable genes. BMC Bioinformatics, 23, 52. (doi: 10.1186/s12859-022-04573-6) (PMID:35073845) (PMCID:PMC8785495)

Drurey, C. et al. (2022) Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products. Journal of Experimental Medicine, 219(1), e20211140. (doi: 10.1084/jem.20211140) (PMID:34779829) (PMCID:PMC8597987)

Jara, M., Barrett, M. , Maes, I., Regnault, C., Imamura, H., Domagalska, M. A. and Dujardin, J.-C. (2022) Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary phase and drug pressure as models. Microorganisms, 10(1), 97. (doi: 10.3390/microorganisms10010097) (PMID:35056546) (PMCID:PMC8781126)

Hildersley, K. A., Mcneilly, T. N., Gillan, V. , Otto, T. D. , Löser, S., Gerbe, F., Jay, P., Maizels, R. M. , Devaney, E. and Britton, C. (2021) Tuft cells increase following ovine intestinal parasite infections and define evolutionarily conserved and divergent responses. Frontiers in Immunology, 12, 781108. (doi: 10.3389/fimmu.2021.781108) (PMID:34880874) (PMCID:PMC8646091)

Smyth, D. J. et al. (2021) Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model. Journal of Biotechnology, 340, pp. 1-12. (doi: 10.1016/j.jbiotec.2021.08.006) (PMID:34390759) (PMCID:PMC8516079)

Espada, C. R., Quilles Jr., J. C., Albuquerque-Wendt, A. , Cruz, M. C., Beneke, T., Lorenzon, L. B., Gluenz, E. , Cruz, A. K. and Uliana, S. R.B. (2021) Effective genome editing in Leishmania (Viannia) braziliensis stably expressing Cas9 and T7 RNA polymerase. Frontiers in Cellular and Infection Microbiology, 11, 772311. (doi: 10.3389/fcimb.2021.772311) (PMID:34858879) (PMCID:PMC8631273)

Maizels, R. M. (2021) Identifying novel candidates and configurations for human helminth vaccines. Expert Review of Vaccines, 20(11), pp. 1389-1393. (doi: 10.1080/14760584.2021.1999810) (PMID:34720028) (PMCID:PMC8734949)

Steketee, P. C., Giordani, F. , Vincent, I. M. , Crouch, K. , Achcar, F. , Dickens, N. J. , Morrison, L. J., MacLeod, A. and Barrett, M. P. (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Silva-Filho, J. L. et al. (2021) Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients. eLife, 10, e71351. (doi: 10.7554/eLife.71351) (PMID:34585667) (PMCID:PMC8536259)

Briggs, E. M., Rojas, F., McCulloch, R. , Matthews, K. R. and Otto, T. D. (2021) Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing. Nature Communications, 12, 5268. (doi: 10.1038/s41467-021-25607-2) (PMID:34489460) (PMCID:PMC8421343)

Briggs, E. M., Warren, F. S.L., Matthews, K. R., McCulloch, R. and Otto, T. D. (2021) Application of single cell transcriptomics to kinetoplastid research. Parasitology, 148(10), pp. 1223-1236. (doi: 10.1017/S003118202100041X) (PMID:33678213) (PMCID:PMC8311972)

White, M. P.J., Smyth, D. J. , Cook, L., Ziegler, S. F., Levings, M. K. and Maizels, R. M. (2021) The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells. Immunology and Cell Biology, 99(8), pp. 848-864. (doi: 10.1111/imcb.12479) (PMID:33988885) (PMCID:PMC9214624)

Drurey, C. and Maizels, R. M. (2021) Helminth extracellular vesicles: interactions with the host immune system. Molecular Immunology, 137, pp. 124-133. (doi: 10.1016/j.molimm.2021.06.017) (PMID:34246032) (PMCID:PMC8636279)

Silva, G. L.A., Tosi, L. R.O., McCulloch, R. and Black, J. A. (2021) Unpicking the roles of DNA damage protein kinases in trypanosomatids. Frontiers in Cell and Developmental Biology, 9, 636615. (doi: 10.3389/fcell.2021.636615) (PMID:34422791) (PMCID:PMC8377203)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)

Oftedal, B. E. et al. (2021) The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function. Communications Biology, 4, 681. (doi: 10.1038/s42003-021-02203-0) (PMID:34083746) (PMCID:PMC8175432)

Biddau, M. et al. (2021) Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes. International Journal for Parasitology, 51(6), pp. 441-453. (doi: 10.1016/j.ijpara.2020.10.011) (PMID:33713652) (PMCID:PMC8126644)

Wichers, J. S. et al. (2021) Common virulence gene expression in adult first-time infected malaria patients and severe cases. eLife, 10, e69040. (doi: 10.7554/elife.69040) (PMID:33908865) (PMCID:PMC8102065)

Espada, C. R., Albuquerque-Wendt, A. , Hornillos, V., Gluenz, E. , Coelho, A. C. and Uliana, S. R.B. (2021) Ros3 (Lem3p/CDC50) gene dosage is implicated in miltefosine susceptibility in Leishmania (Viannia) braziliensis clinical isolates and in Leishmania (Leishmania) major. ACS Infectious Diseases, 7(4), pp. 849-858. (doi: 10.1021/acsinfecdis.0c00857) (PMID:33724800) (PMCID:PMC8042657)

Annese, V. F. et al. (2021) A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems and Nanoengineering, 7, 21. (doi: 10.1038/s41378-021-00243-4) (PMID:34567735) (PMCID:PMC8433377)

Milne, K. et al. (2021) Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum. eLife, 10, e62800. (doi: 10.7554/elife.62800) (PMID:33648633) (PMCID:PMC7924948)

Villafraz, O. et al. (2021) Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline. PLoS Pathogens, 17(3), e1009204. (doi: 10.1371/journal.ppat.1009204) (PMID:33647053) (PMCID:PMC7951978)

Simwela, N., Hughes, K. R., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)

Mina, J. G.M. et al. (2021) Antileishmanial chemotherapy through clemastine fumarate mediated inhibition of the Leishmania inositol phosphorylceramide synthase. ACS Infectious Diseases, 7(1), pp. 47-63. (doi: 10.1021/acsinfecdis.0c00546) (PMID:33291887) (PMCID:PMC7802075)

Cockram, P. E., Dickie, E. A., Barrett, M. P. and Smith, T. K. (2020) Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei. PLoS Neglected Tropical Diseases, 14(12), e0008928. (doi: 10.1371/journal.pntd.0008928) (PMID:33275612) (PMCID:PMC7744056)

Morang’a, C. M. et al. (2020) Machine learning approaches classify clinical malaria outcomes based on haematological parameters. BMC Medicine, 18, 375. (doi: 10.1186/s12916-020-01823-3) (PMID:33250058) (PMCID:PMC7702702)

Hentzschel, F., Obrova, K. and Marti, M. (2020) No evidence for Ago2 translocation from the host erythrocyte into the Plasmodium parasite. Wellcome Open Research, 5, 92. (doi: 10.12688/wellcomeopenres.15852.2) (PMID:33501380) (PMCID:PMC7808052)

Simwela, N., Stokes, B. H., Aghabi, D., Bogyo, M., Fidock, D. A. and Waters, A. (2020) Plasmodium berghei K13 mutations mediate in vivo artemisinin resistance that is reversed by proteasome inhibition. mBio, 11, e02312-20. (doi: 10.1128/mBio.02312-20) (PMID:33173001) (PMCID:PMC7667033)

Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)

Blackburn, G. et al. (2020) Running on empty: a metabolomics approach to investigating changing energy metabolism during fasted exercise and rest. Metabolites, 10(10), 399. (doi: 10.3390/metabo10100399) (PMID:33050077) (PMCID:PMC7600507)

Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)

White, M. P., Johnston, C. J., Grainger, J. R., Konkel, J. E., O'Connor, R. A., Anderton, S. M. and Maizels, R. M. (2020) The helminth parasite Heligmosomoides polygyrus attenuates EAE in an IL-4Rα-dependent manner. Frontiers in Immunology, 11, 1830. (doi: 10.3389/fimmu.2020.01830) (PMID:33117327) (PMCID:PMC7552805)

Damasceno, J. D., Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)

Drurey, C. , Coakley, G. and Maizels, R. M. (2020) Extracellular vesicles: new targets for vaccines against helminth parasites. International Journal for Parasitology, 50(9), pp. 623-633. (doi: 10.1016/j.ijpara.2020.04.011) (PMID:32659278)

Moxon, C. A. et al. (2020) Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), pp. 2851-2864. (doi: 10.1182/bloodadvances.2019001258) (PMID:32579667) (PMCID:PMC7362376)

Damasceno, J. D., Reis-Cunha, J., Crouch, K. , Beraldi, D., Lapsley, C., Tosi, L. R.O., Bartholomeu, D. and McCulloch, R. (2020) Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication. PLoS Genetics, 16(7), e1008828. (doi: 10.1371/journal.pgen.1008828) (PMID:32609721) (PMCID:PMC7360064)

de Araujo, C. B. et al. (2020) Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, 21, 414. (doi: 10.1186/s12864-020-06803-8) (PMID:32571205) (PMCID:PMC7310030)

Daly, R. et al. (2020) Changes in plasma itaconate elevation in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation. Metabolites, 10(6), 241. (doi: 10.3390/metabo10060241) (PMID:32531990) (PMCID:PMC7344783)

Simwela, N., Hughes, K. R., Roberts, A. B., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)

Doleželová, E., Kunzová, M., Dejung, M., Levin, M., Panicucci, B., Regnault, C., Janzen, C. J., Barrett, M. P. , Butter, F. and Zíková, A. (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei. PLoS Biology, 18(6), e3000741. (doi: 10.1371/journal.pbio.3000741) (PMID:32520929) (PMCID:PMC7307792)

Zoltner, M. et al. (2020) Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), pp. 8331-8347. (doi: 10.1074/jbc.ra120.012355) (PMID:32354742) (PMCID:PMC7294092)

Patil, H., Hughes, K. R., Lemgruber Soares, L. , Philip, N., Dickens, N. , Starnes, G. L. and Waters, A. P. (2020) Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A. PLoS Pathogens, 16(5), e1008091. (doi: 10.1371/journal.ppat.1008091) (PMID:32463831) (PMCID:PMC7255598)

Grazielle-Silva, V., Zeb, T. F., Machado, C. R., McCulloch, R. and Teixeira, S. M. R. (2020) Trypanosoma brucei and Trypanosoma cruzi DNA mismatch repair proteins act differently in the response to DNA damage caused by oxidative stress. Frontiers in Cellular and Infection Microbiology, 10, 154. (doi: 10.3389/fcimb.2020.00154) (PMID:32373549) (PMCID:PMC7176904)

Briggs, E. M., Marques, C. A., Reis-Cunha, J., Black, J., Campbell, S., Damasceno, J., Bartholomeu, D., Crouch, K. and McCulloch, R. (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)

Dickie, E. A., Giordani, F. , Gould, M. K., Maeser, P., Burri, C., Mottram, J. C. , Rao, S. P.S. and Barrett, M. P. (2020) New drugs for human African trypanosomiasis:a twenty first century success story. Tropical Medicine and Infectious Disease, 5(1), 29. (doi: 10.3390/tropicalmed5010029) (PMID:32092897) (PMCID:PMC7157223)

Pountain, A. W. and Barrett, M. P. (2019) Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant. Wellcome Open Research, 4, 176. (doi: 10.12688/wellcomeopenres.15452.1) (PMID:32133420) (PMCID:PMC7041363)

Filbey, K. J. et al. (2019) Macrophage migration inhibitory factor (MIF) is essential for Type 2 effector cell immunity to an intestinal helminth parasite. Frontiers in Immunology, 10, 2375. (doi: 10.3389/fimmu.2019.02375) (PMID:31708913) (PMCID:PMC6821780)

Diaz-Albiter, H. M., Regnault, C., Alpizar-Sosa, E. A., McGuinness, D., Barrett, M. P. and Dillon, R. J. (2018) Non-invasive visualisation and identification of fluorescent. Wellcome Open Research, 3, 160. (doi: 10.12688/wellcomeopenres.14910.1) (PMID:30756095) (PMCID:PMC6367660)

Kovářová, J., Nagar, R., Faria, J., Ferguson, M. A.J., Barrett, M. P. and Horn, D. (2018) Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens, 14(12), e1007475. (doi: 10.1371/journal.ppat.1007475) (PMID:30589893) (PMCID:PMC6307712)

Almeida, L. V., Coqueiro-Dos-Santos, A., Rodriguez-Luiz, G. F., McCulloch, R. , Bartholomeu, D. C. and Reis-Cunha, J. L. (2018) Chromosomal copy number variation analysis by next generation sequencing confirms ploidy stability in Trypanosoma brucei subspecies. Microbial Genomics, 4(10), e000223. (doi: 10.1099/mgen.0.000223) (PMID:30256189) (PMCID:PMC6249438)

Rolot, M. et al. (2018) Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection. Nature Communications, 9, 4516. (doi: 10.1038/s41467-018-06978-5) (PMID:30375396) (PMCID:PMC6207712)

Matthews, K. R., McCulloch, R. and Morrison, L. J. (2015) The within-host dynamics of African trypanosome infections. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1675), 20140288. (doi: 10.1098/rstb.2014.0288) (PMID:26150654) (PMCID:PMC4528486)

This list was generated on Thu Dec 8 13:49:39 2022 GMT.