Circulating biomarkers for therapeutic monitoring of anti-cancer agents

Janse van Rensburg, H. J., Spiliopoulou, P. and Siu, L. L. (2022) Circulating biomarkers for therapeutic monitoring of anti-cancer agents. Oncologist, 27(5), pp. 352-362. (doi: 10.1093/oncolo/oyac047) (PMID:35285488) (PMCID:PMC9074993)

Abstract

Circulating biomarkers have emerged as valuable surrogates for evaluating disease states in solid malignancies. Their relative ease of access and rapid turnover has bolstered clinical applications in monitoring treatment efficacy and cancer progression. In this review, the roles of various circulating biomarkers in monitoring treatment response are described. Non-specific markers of disease burden, tumor markers (eg CA 125, CEA, PSA, etc.), circulating tumor cells, nucleic acids, exosomes, and metabolomic arrays are highlighted. Specifically, the discovery of each of these markers is reviewed, with examples illustrating their use in influencing treatment decisions, and barriers to their application noted where these exist. Finally, opportunities for future work using these circulating biomarkers are discussed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Spiliopoulou, Dr Pavlina
• Authors: Janse van Rensburg, H. J., Spiliopoulou, P., and Siu, L. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Oncologist
• Publisher: Oxford University Press
• ISSN: 1083-7159
• ISSN (Online): 1549-490X
• Published Online: 14 March 2022
• Copyright Holders: Copyright © The Author(s) 2022
• First Published: First published in The Oncologist 27(5):352-362
• Publisher Policy: Reproduced under a Creative Commons licence