Rojas-Sereno, Z. E., Streicker, D. G. , Suarez-Yana, T., Lineros, M., Yung, V., Godreuil, S. and Benavides, J. A. (2023) Detection of antimicrobial-resistant enterobacterales in insectivorous bats from Chile. Royal Society Open Science, 10(11), 231177. (doi: 10.1098/rsos.231177) (PMID:38026036) (PMCID:PMC10645110)
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Abstract
Enterobacterales of clinical importance for humans and domestic animals are now commonly detected among wildlife worldwide. However, few studies have investigated their prevalence among bats, particularly in bat species living near humans. In this study, we assessed the occurrence of Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemase-resistant (CR) Enterobacterales in rectal swabs of bats submitted to the Chilean national rabies surveillance program from 2021 to 2022. From the 307 swabs screened, 47 (15%) harboured cefotaxime-resistant Enterobacterales. Bats carrying these bacteria originated from 9 out of the 14 Chilean regions. Most positive samples were obtained from Tadarida brasiliensis (n = 42), but also Lasiurus varius, L. cinereus and Histiotus macrotus. No Enterobacterales were resistant to imipenem. All ESBL-Enterobacterales were confirmed as Rahnella aquatilis by MALDI-TOF. No other ESBL or CR Enterobacterales were detected. To our knowledge, this is the first screening of antibiotic-resistant bacteria in wild bats of Chile, showing the bat faecal carriage of R. aquatilis naturally resistant to cephalosporins, but also including acquired resistance to important antibiotics for public health such as amoxicillin with clavulanic acid. Our results suggest unknown selective pressures on R. aquatilis, but low or no carriage of ESBL or CR Escherichia coli and Klebsiella spp. Future studies should assess the zoonotic and environmental implications of R. aquatilis, which are likely present in the guano left by bats roosting in human infrastructures.
| Item Type: | Articles |
|---|---|
| Additional Information: | Lab work and writing work were funded by the National Agency for Research and Development (ANID) FONDECYT Iniciación 11181017, awarded to JB and Beca Doctorado Nacional 21201076, awarded to Z.E.R.-S., D.G.S. was supported by a Wellcome Trust Senior Research Fellowship (217221/Z/19/Z). |
| Keywords: | Tadarida brasiliensis, antimicrobial resistance, Rahnella aquatilis, urban, extended-spectrum-beta-lactamase-producing, Latin America. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Streicker, Professor Daniel and Rojas Sereno, Zulma and Benavides, Dr Julio |
| Creator Roles: | Rojas Sereno, Z.Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review and editing Streicker, D.Conceptualization, Supervision, Writing – original draft, Writing – review and editing Benavides, J.Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review and editing |
| Authors: | Rojas-Sereno, Z. E., Streicker, D. G., Suarez-Yana, T., Lineros, M., Yung, V., Godreuil, S., and Benavides, J. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Royal Society Open Science |
| Publisher: | The Royal Society |
| ISSN: | 2054-5703 |
| ISSN (Online): | 2054-5703 |
| Published Online: | 08 November 2023 |
| Copyright Holders: | Copyright: © 2023 The Authors |
| First Published: | First published in Royal Society Open Science 10(11): 231177 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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