Watt, J. K., Dickie, D. A. , Lyall, D. , Ward, J. , Ho, F., Dawson, J. and Quinn, T. J. (2023) Normative values of the brain health index in UK biobank. Neuroimage: Reports, 3(3), 100176. (doi: 10.1016/j.ynirp.2023.100176)
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Abstract
The Brain Health Index (BHI) is an automated approach to quantifying brain integrity, combining different types of structural magnetic resonance imaging (MRI). Normative values derived from generally healthy individuals provide a vital baseline for understanding neurodegenerative change. Although commonplace in other areas of medicine, these are not always established when proposing new analytical approaches using MRI. The scale and quality of the UK Biobank imaging cohort (approximately N = 50k, as of 2022) allows for derivation of such values, and the wealth of additional lifestyle, physiological and demographic data enables validation of BHI through comparison with more established variables which may affect brain health.
| Item Type: | Articles |
|---|---|
| Additional Information: | JKW is funded by a Chief Scientist Office Research Grant (Reference: TCS/19/31). JW is funded by the Aitchison Family Bequest. This research has been conducted using the UK Biobank Resource under Application Number 17869. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ward, Dr Joey and Ho, Dr Frederick and Watt, Dr Jodi and Dickie, Dr David Alexander and Quinn, Professor Terry and Dawson, Professor Jesse and Lyall, Dr Donald |
| Creator Roles: | Watt, J.Conceptualization, Methodology, Investigation, Software, Formal analysis, Visualization, Data curation, Writing – original draft, Writing – review and editing Dickie, D. A.Conceptualization, Methodology, Software, Resources, Data curation, Supervision, Writing – review and editing Lyall, D.Formal analysis, Writing – review and editing Ward, J.Data curation, Writing – review and editing Ho, F.Formal analysis, Writing – review and editing Dawson, J.Conceptualization, Methodology, Supervision, Writing – review and editing Quinn, T.Conceptualization, Methodology, Supervision, Writing – review and editing |
| Authors: | Watt, J. K., Dickie, D. A., Lyall, D., Ward, J., Ho, F., Dawson, J., and Quinn, T. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing |
| Journal Name: | Neuroimage: Reports |
| Publisher: | Elsevier |
| ISSN: | 2666-9560 |
| ISSN (Online): | 2666-9560 |
| Published Online: | 20 June 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Neuroimage: Reports 3(3):100176 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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