Physics-informed graph neural network emulation of soft-tissue mechanics computer methods in applied mechanics and engineering

Dalton, D., Husmeier, D. and Gao, H. (2023) Physics-informed graph neural network emulation of soft-tissue mechanics computer methods in applied mechanics and engineering. Computer Methods in Applied Mechanics and Engineering, 417(A), 116351. (doi: 10.1016/j.cma.2023.116351)

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Abstract

Modern computational soft-tissue mechanics models have the potential to offer unique, patient-specific diagnostic insights. The deployment of such models in clinical settings has been limited however, due to the excessive computational costs incurred when performing mechanical simulations using conventional numerical solvers. An alternative approach to obtaining results in clinically relevant time frames is to make use of a computationally efficient surrogate model, called an emulator, in place of the numerical simulator. In this work, we propose an emulation framework for soft-tissue mechanics which builds on traditional approaches in two ways. Firstly, we use a Graph Neural Network (GNN) to perform emulation. GNNs can naturally handle the unique soft-tissue geometry of a given patient, without requiring any low-order approximations to be made. Secondly, the emulator is trained in a physics-informed manner to minimise a potential energy functional, meaning that no costly numerical simulations are required for training. We present results showing that our framework allows for highly accurate emulation for a range of soft-tissue mechanical models, while making predictions several orders of magnitude more quickly than the simulator.

Item Type:Articles
Additional Information:This work has been funded by the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom, grant reference numbers EP/T017899/1, EP/S030875/1 and EP/S020950/1.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dalton, David and Gao, Dr Hao and Husmeier, Professor Dirk
Authors: Dalton, D., Husmeier, D., and Gao, H.
College/School:College of Science and Engineering
College of Science and Engineering > School of Mathematics and Statistics > Mathematics
College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Computer Methods in Applied Mechanics and Engineering
Publisher:Elsevier
ISSN:0045-7825
ISSN (Online):1879-2138
Published Online:16 September 2023
Copyright Holders:Copyright © 2023 The Author(s).
First Published:First published in Computer Methods in Applied Mechanics and Engineering 417(A):116351
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308255The SofTMech Statistical Emulation and Translation HubDirk HusmeierEngineering and Physical Sciences Research Council (EPSRC)EP/T017899/1M&S - Statistics
303232EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S030875/1M&S - Mathematics
303231A whole-heart model of multiscale soft tissue mechanics and fluid structureinteraction for clinical applications (Whole-Heart-FSI)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S020950/1M&S - Mathematics