Self-sorting in diastereomeric mixtures of functionalized dipeptides

Guan, Q., McAulay, K., Xu, T., Rogers, S. E., Edwards-Gayle, C., Schweins, R., Cui, H., Seddon, A. M. and Adams, D. J. (2023) Self-sorting in diastereomeric mixtures of functionalized dipeptides. Biomacromolecules, 24(6), pp. 2847-2855. (doi: 10.1021/acs.biomac.3c00246) (PMID:37257089) (PMCID:PMC10265659)

Abstract

Self-sorting in functionalized dipeptide systems can be driven by the chirality of a single amino acid, both at a high pH in the micellar state and at a low pH in the gel state. The structures formed are affected to some degree by the relative concentrations of each component showing the complexity of such an approach. The structures underpinning the gel network are predefined by the micellar structures at a high pH. Here, we describe the systems prepared from two dipeptide-based gelators that differ only by the chirality of one of the amino acids. We provide firm evidence for self-sorting in the micellar and gel phases using small-angle neutron scattering and cryo-transmission electron microscopy (cryo-TEM), showing that complete self-sorting occurs across a range of relative concentrations.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McAulay, Dr Kate and Adams, Dave and Guan, Qingwen
• Authors: Guan, Q., McAulay, K., Xu, T., Rogers, S. E., Edwards-Gayle, C., Schweins, R., Cui, H., Seddon, A. M., and Adams, D. J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Biomacromolecules
• Publisher: American Chemical Society
• ISSN: 1525-7797
• ISSN (Online): 1526-4602
• Published Online: 31 May 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Biomacromolecules 24(6):2847-2855
• Publisher Policy: Reproduced under a Creative Commons license

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
174004		Multicomponent Supramolecular Hydrogels	Dave Adams	Engineering and Physical Sciences Research Council (EPSRC)	EP/L021978/2	Chemistry