Antifungal therapy of Candida biofilms: past, present and future

Ajetunmobi, O. H., Badali, H., Romo, J. A., Ramage, G. and Lopez-Ribot, J. L. (2023) Antifungal therapy of Candida biofilms: past, present and future. Biofilm, 5, 100126. (doi: 10.1016/j.bioflm.2023.100126) (PMID:37193227) (PMCID:PMC10182175)

Abstract

Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections. There is a scarcity of antifungal agents, and their effectiveness, particularly against biofilms, is limited. Here we provide a historical perspective on antifungal agents and therapy of Candida biofilms. As we reflect upon the past, consider the present, and look towards the future of antifungal therapy of Candida biofilms, we believe that there are reasons to remain optimistic, and that the major challenges of Candida biofilm therapy can be conquered within a reasonable timeframe.

• Item Type: Articles
• Additional Information: Biofilm work in the JL-R laboratory is supported by NIH grants R33AI140823 and R21 R21AI156100 from the National Institute of Allergy and Infectious Diseases. Additional support was provided by the Margaret Batts Tobin Foundation, San Antonio, TX.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ramage, Professor Gordon

Creator Roles

Ramage, G.: Writing – original draft, Writing – review and editing

• Authors: Ajetunmobi, O. H., Badali, H., Romo, J. A., Ramage, G., and Lopez-Ribot, J. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Biofilm
• Publisher: Elsevier
• ISSN: 2590-2075
• ISSN (Online): 2590-2075
• Published Online: 23 April 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Biofilm 5: 100126
• Publisher Policy: Reproduced under a Creative Commons License