Regulatory T cells in parasite infections: susceptibility, specificity and specialisation

McManus, C. M. and Maizels, R. M. (2023) Regulatory T cells in parasite infections: susceptibility, specificity and specialisation. Trends in Parasitology, 39(7), pp. 547-562. (doi: 10.1016/ (PMID:37225557)

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Regulatory T cells (Tregs) are essential to control immune system responses to innocuous self-specificities, intestinal and environmental antigens. However, they may also interfere with immunity to parasites, particularly in chronic infection. Susceptibility to many parasite infections is, to a greater or lesser extent, controlled by Tregs, but often they play a more prominent role in moderating the immunopathological consequences of parasitism, and dampening bystander reactions in an antigen-nonspecific manner. More recently, Treg subtypes have been defined which may preferentially act in different contexts; we also discuss the degree to which this specialisation is now being mapped onto how Tregs maintain the delicate balance between tolerance, immunity, and pathology in infection.

Item Type:Articles
Additional Information:We gratefully acknowledge funding support from the Wellcome Trust through an Investigator Award to RMM (Ref 219530), a University of Glasgow PhD studentship for CMM, and core funding through the Wellcome Centre for Integrative Parasitology (Ref 104111).
Glasgow Author(s) Enlighten ID:McManus, Miss Caitlin and Maizels, Professor Rick
Authors: McManus, C. M., and Maizels, R. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Trends in Parasitology
Publisher:Elsevier (Cell Press)
ISSN (Online):1471-5007
Published Online:22 May 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Trends in Parasitology 39(7): 547-562
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308411Molecular and Cellular Interactions in Helminth InfectionsRichard MaizelsWellcome Trust (WELLCOTR)219530/Z/19/ZIII - Parasitology
170547The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/ZIII - Parasitology