Regulatory T cells in parasite infections: susceptibility, specificity and specialisation

McManus, C. M. and Maizels, R. M. (2023) Regulatory T cells in parasite infections: susceptibility, specificity and specialisation. Trends in Parasitology, 39(7), pp. 547-562. (doi: 10.1016/j.pt.2023.04.002) (PMID:37225557)

Abstract

Regulatory T cells (Tregs) are essential to control immune system responses to innocuous self-specificities, intestinal and environmental antigens. However, they may also interfere with immunity to parasites, particularly in chronic infection. Susceptibility to many parasite infections is, to a greater or lesser extent, controlled by Tregs, but often they play a more prominent role in moderating the immunopathological consequences of parasitism, and dampening bystander reactions in an antigen-nonspecific manner. More recently, Treg subtypes have been defined which may preferentially act in different contexts; we also discuss the degree to which this specialisation is now being mapped onto how Tregs maintain the delicate balance between tolerance, immunity, and pathology in infection.

• Item Type: Articles
• Additional Information: We gratefully acknowledge funding support from the Wellcome Trust through an Investigator Award to RMM (Ref 219530), a University of Glasgow PhD studentship for CMM, and core funding through the Wellcome Centre for Integrative Parasitology (Ref 104111).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McManus, Miss Caitlin and Maizels, Professor Rick
• Authors: McManus, C. M., and Maizels, R. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Trends in Parasitology
• Publisher: Elsevier (Cell Press)
• ISSN: 1471-4922
• ISSN (Online): 1471-5007
• Published Online: 22 May 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Trends in Parasitology 39(7): 547-562
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
308411		Molecular and Cellular Interactions in Helminth Infections	Richard Maizels	Wellcome Trust (WELLCOTR)	219530/Z/19/Z	III - Parasitology
170547		The Wellcome Centre for Molecular Parasitology ( Core Support )	Andrew Waters	Wellcome Trust (WELLCOTR)	104111/Z/14/Z	III - Parasitology