Milligan, G. (2023) GPR35: from enigma to therapeutic target. Trends in Pharmacological Sciences, 44(5), pp. 263-273. (doi: 10.1016/j.tips.2023.03.001) (PMID:37002007)
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Abstract
The orphan G-protein-coupled receptor 35 (GPR35), although poorly characterised, is attracting considerable interest as a therapeutic target. Marked differences in pharmacology between human and rodent orthologues of the receptor and a dearth of antagonists with affinity for mouse and rat GPR35 have previously restricted the use of preclinical disease models. The development of improved ligands, novel transgenic knock-in mouse lines, and detailed analysis of the disease relevance of single-nucleotide polymorphisms (SNPs) have greatly enhanced understanding of the key roles of GPR35 and have stimulated efforts towards disease-targeted proof-of-concept studies. In this opinion article, new information on the biology of the receptor is considered, whilst insight into how GPR35 is currently being assessed for therapeutic utility – in areas ranging from inflammatory bowel diseases to nonalcoholic steatohepatitis and various cancers – is also provided.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work is supported by grants from UKRI, Medical Research Council (grant number MR/X008827/1) and Biotechnology and Biosciences Research Council (grant number BB/P000649/1) to GM. |
| Keywords: | G protein-coupled receptor, orphan receptor, kynurenic acid, fatty liver disease, inflammatory 14 bowel diseases, digestive system cancers. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Milligan, Professor Graeme |
| Authors: | Milligan, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Trends in Pharmacological Sciences |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 0165-6147 |
| ISSN (Online): | 1873-3735 |
| Published Online: | 30 March 2023 |
| Copyright Holders: | Copyright © 2023 Elsevier Ltd. |
| First Published: | First published in Trends in Pharmacological Sciences 44(5): 263-273 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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