Drurey, C. and Maizels, R. M. (2021) Helminth extracellular vesicles: interactions with the host immune system. Molecular Immunology, 137, pp. 124-133. (doi: 10.1016/j.molimm.2021.06.017) (PMID:34246032) (PMCID:PMC8636279)
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Abstract
As long-lived parasites, helminths depend upon immunomodulation of their hosts for survival. The release of excretory-secretory (ES) products, including proteins, lipids and RNAs is how successful host manipulation is achieved. It has recently been discovered that the ES products of helminths contain extracellular vesicles (EVs), with every species investigated found to secrete these lipid-bound structures. EVs are perfect for packaging and delivering immune modulators to target cell types. This review outlines the research carried out on helminth EVs and their constituents thus far, as well as their interaction with components of the mammalian immune system. We discuss how targeting EVs will aid treatment of helminth infection and consider how EVs and their immunomodulatory cargo could be used as therapeutics as we progress through this exciting era.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Drurey, Claire and Maizels, Professor Rick |
Creator Roles: | Drurey, C.Conceptualization, Writing – original draft, Writing – review and editing Maizels, R. M.Conceptualization, Writing – review and editing, Funding acquisition |
Authors: | Drurey, C., and Maizels, R. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Molecular Immunology |
Publisher: | Elsevier |
ISSN: | 0161-5890 |
ISSN (Online): | 1872-9142 |
Published Online: | 07 July 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Molecular Immunology 137: 124-133 |
Publisher Policy: | Reproduced under a Creative Commons License |
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