The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116(14), pp. 2185-2196. (doi: 10.1093/cvr/cvaa209) (PMID:32702087) (PMCID:PMC7454350)

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Background: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.

Item Type:Articles
Keywords:SARS-CoV-2, myocardial inflammation, myocardial infarction, myocardial injury, imaging, biomarkers.
Glasgow Author(s) Enlighten ID:Macfarlane, Professor Peter and McConnachie, Professor Alex and Gillespie, Dr Lynsey and Kean, Ms Sharon and Ho, Dr Antonia and Corcoran, Dr David and Mangion, Dr Kenneth and Lowe, Dr David and Morrow, Dr Andrew and Bagot, Dr Catherine and Touyz, Professor Rhian and Berry, Professor Colin and Delles, Professor Christian and Wright, Dr Sylvia and Blyth, Professor Kevin and Lang, Dr Ninian and Roditi, Dr Giles and Wereski, Dr Ryan and Sattar, Professor Naveed and Sykes, Dr Robert and Bayes, Dr Hannah
Authors: Mangion, K., Morrow, A., Bagot, C., Bayes, H., Blyth, K. G., Church, C., Corcoran, D., Delles, C., Gillespie, L., Grieve, D., Ho, A., Kean, S., Lang, N. N., Lennie, V., Lowe, D., Kellman, P., Macfarlane, P. W., McConnachie, A., Roditi, G., Sykes, R., Touyz, R. M., Sattar, N., Wereski, R., Wright, S., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Cardiovascular Research
Publisher:Oxford University Press
ISSN (Online):1755-3245
Published Online:23 July 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Cardiovascular Research 116(14):2185–2196
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
311300CSO covid 19 portfolioIain McInnesChief Scientist Office (CSO)COV/GLA/PortfolioIII - Immunology