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Briggs, E., Crouch, K. , Lemgruber Soares, L., Hamilton, G., Lapsley, C. and McCulloch, R. (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, (doi:10.1093/nar/gkz644) (PMID:31350892) (Early Online Publication)

Nenarokova, A., Záhonová, K., Krasilnikova, M., Gahura, O., McCulloch, R. , Zíková, A., Yurchenko, V. and Lukeš, J. (2019) Causes and effects of loss of classical non-homologous end joining pathway in parasitic eukaryotes. mBio, 10(4), e01541-9. (doi:10.1128/mBio.01541-19) (PMID:31311886) (PMCID:PMC6635534)

Vieira Da Rocha, J.P., Passos-Silva, D.G., Mendes, I.C., Rocha, E.A., Gomes, D.A., Machado, C.R. and McCulloch, R. (2019) The DNA damage response is developmentally regulated in the African trypanosome. DNA Repair, 73, pp. 78-90. (doi:10.1016/j.dnarep.2018.11.005) (PMID:30470509) (PMCID:PMC6329875)

Damasceno, J. D., Obonaga, R., Silva, G. L.A., Reis-Cunha, J. L., Duncan, S. M., Bartholomeu, D. C., Mottram, J. C. , McCulloch, R. and Tosi, L. R.O. (2018) Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania. Nucleic Acids Research, 46(22), pp. 11835-11846. (doi:10.1093/nar/gky1017) (PMID:30380080) (PMCID:PMC6294564)

Briggs, E., Hamilton, G., Crouch, K. , Lapsley, C. and McCulloch, R. (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi:10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, E., Crouch, K. , Lemgruber, L., Lapsley, C. and McCulloch, R. (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi:10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

Santos da Silva, M., Hovel-Miner, G. A., Briggs, E. M., Elias, M. C. and McCulloch, R. (2018) Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLoS Pathogens, 14(11), e1007321. (doi:10.1371/journal.ppat.1007321) (PMID:30440029) (PMCID:PMC6237402)

Marques, C. A. and McCulloch, R. (2018) Conservation and variation in strategies for DNA replication of kinetoplastid nuclear genomes. Current Genomics, 19(2), pp. 98-109. (doi:10.2174/1389202918666170815144627) (PMID:29491738) (PMCID:PMC5814967)

McCulloch, R. , Cobbold, C. A. , Figueiredo, L., Jackson, A., Morrison, L. J., Mugnier, M. R., Papavasiliou, N., Schnaufer, A. and Matthews, K. (2017) Emerging challenges in understanding trypanosome antigenic variation. Emerging Topics in Life Sciences, 1(6), pp. 585-592. (doi:10.1042/ETLS20170104)

da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A. , McCulloch, R. , Tosi, L. R. O. and Elias, M. C. (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11), pp. 858-874. (doi:10.1016/j.pt.2017.08.002) (PMID:28844718) (PMCID:PMC5662062)

Stortz, J. A. et al. (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS Pathogens, 13(7), e1006477. (doi:10.1371/journal.ppat.1006477) (PMID:28742144) (PMCID:PMC5542689)

Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi:10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)

Devlin, R., Marques, C. A. and McCulloch, R. (2017) Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome? Current Genetics, 63(3), pp. 441-449. (doi:10.1007/s00294-016-0662-7) (PMID:27822899) (PMCID:PMC5422504)

Cabrera, G., Silva, V. G., Mendes, I. C., Machado, C. R. and McCulloch, R. (2017) Genome maintenance in Trypanosomatids. In: Santos da Silva, M. and Cano, M. I. N. (eds.) Molecular and Cellular Biology of Pathogenic Trypanosomatids. Series: Frontiers in parasitology, 1. Bentham Science, pp. 195-260. ISBN 9781681084060 (doi:10.2174/9781681084053117010008)

Marques, C. A. , Tiengwe, C., Lemgruber Soares, L., Damasceno, J. D., Scott, A., Paape, D. , Marcello, L. and McCulloch, R. (2016) Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Research, 44(10), pp. 4763-4784. (doi:10.1093/nar/gkw147) (PMID:26951375) (PMCID:PMC4889932)

Damasceno, J. D., Obonaga, R., Santos, E. V., Scott, A., McCulloch, R. and Tosi, L. R.O. (2016) Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania. Molecular Microbiology, 101(6), pp. 1054-1068. (doi:10.1111/mmi.13441) (PMID:27301589) (PMCID:PMC5453112)

McCulloch, R. and Navarro, M. (2016) The protozoan nucleus. Molecular and Biochemical Parasitology, 209(1-2), pp. 76-87. (doi:10.1016/j.molbiopara.2016.05.002) (PMID:27181562)

Devlin, R., Marques, C. A. , Paape, D. , Prorocic, M., Zurita-Leal, A. C., Campbell, S. J., Lapsley, C., Dickens, N. and McCulloch, R. (2016) Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. eLife, 5, e12765. (doi:10.7554/eLife.12765) (PMID:27228154) (PMCID:PMC4946898)

Marques, C. A. , Dickens, N. J. , Paape, D. , Campbell, S. J. and McCulloch, R. (2015) Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe. Genome Biology, 16, 230. (doi:10.1186/s13059-015-0788-9) (PMID:26481451) (PMCID:PMC4612428)

Grazielle-Silva, V., Zeb, T.F., Bolderson, J., Campos, P.C., Miranda, J.B., Alves, C.L., Machado, C.R., McCulloch, R. and Teixeira, S.M. R. (2015) Distinct phenotypes caused by mutation of MSH2 in trypanosome insect and mammalian life cycle forms are associated with parasite adaptation to oxidative stress. PLoS Neglected Tropical Diseases, 9(6), e0003870. (doi:10.1371/journal.pntd.0003870) (PMID:26083967) (PMCID:PMC4470938)

This list was generated on Sat Dec 7 12:39:38 2019 GMT.