Browse by Research Project Code

Williams, R.A.M, Mottram, J.C., and Coombs, G.H. (2013) Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major. Journal of Biological Chemistry, 288 (5). pp. 3678-3690. ISSN 0021-9258 (doi:10.1074/jbc.M112.415372)

McLuskey, K., Rudolf, J., Proto, W.R., Isaacs, N.W., Coombs, G.H., Moss, C., and Mottram, J.C. (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences of the United States of America, 109 (19). pp. 7469-7474. ISSN 0027-8424 (doi:10.1073/pnas.1200885109)

Morrison, L.S. et al. (2012) Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation. Cellular Microbiology, 14 (8). pp. 1271-1286. ISSN 1462-5814 (doi:10.1111/j.1462-5822.2012.01798.x)

Ambit, A., Woods, K.L., Cull, B., Coombs, G.H., and Mottram, J.C. (2011) Morphological events during the cell cycle of Leishmania major. Eukaryotic Cell, 10 (11). pp. 1429-1438. ISSN 1535-9778 (doi:10.1128/EC.05118-11)

Munday, J.C., McLuskey, K., Brown, E., Coombs, G.H., and Mottram, J.C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175 (1). pp. 49-57. ISSN 0166-6851 (doi:10.1016/j.molbiopara.2010.09.003)

Duszenko, M. et al. (2011) Autophagy in protists. Autophagy, 7 (2). pp. 127-158. ISSN 1554-8627 (doi:10.4161/auto.7.2.13310)

Berg, M. et al. (2010) Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (6). pp. 2001-2006. ISSN 0960-894X (doi:10.1016/j.bmcl.2010.01.099)

Engels, K., Beyer, C., Suárez Fernández, M.L., Bender, F., Gaßel, M., Unden, G., Marhöfer, R.J., Mottram, J.M., and Selzer, P.M. (2010) Inhibition of Eimeria tenella CDK-Related kinase 2: from target identification to lead compounds. ChemMedChem, 5 (8). pp. 1259-1271. ISSN 1860-7179 (doi:10.1002/cmdc.201000157)

Steert, K. et al. (2010) α-Ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. ChemMedChem, 5 (10). pp. 1734-1748. ISSN 1860-7179 (doi:10.1002/cmdc.201000265)

El-Fadili, A.K., Zangger, H., Desponds, C., Gonzalez, I.J., Zalila, H., Schaff, C., Ives, A., Masina, S., Mottram, J.C., and Fasel, N. (2010) Cathepsin B-like and cell death in the unicellular human pathogen Leishmania. Cell Death and Disease, 1 (e71). pp. 1-9. ISSN 2041-4889 (doi:10.1038/cddis.2010.51)

Bryson, K., Besteiro, S., McGachy, H.A., Coombs, G.H., Mottram, J., and Alexander, J.C. (2009) Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response. Infection and Immunity, 77 (7). pp. 2971-2978. ISSN 0019-9567 (doi:10.1128/IAI.00558-08)

Williams, R.A., Westrop, G.D., and Coombs, G.H. (2009) Two pathways for cysteine biosynthesis in Leishmania major. Biochemical Journal, 420 (3). pp. 451-462. ISSN 0264-6021 (doi:10.1042/BJ20082441)

Richardson, J.M., Morrison, L., Bland, N.D., Bruce, S., Coombs, G.H., Mottram, J.C., and Walkinshaw, M.D. (2009) Structures of Leishmania major orthologues of macrophage migration inhibitory factor. Biochemical and Biophysical Research Communications, 380 (3). pp. 442-448. ISSN 0006-291X (doi:10.1016/j.bbrc.2009.01.030)

Bryson, K., Besteiro, S., McGachy, H.A., Coombs, G.H., Mottram, J.C., and Alexander, J. (2009) Over-expression of the natural inhibitor of cysteine peptidases, ICP, in Leishmania mexicana leads to reduced virulence and a Th1 response. Infection and Immunity, 77 (7). pp. 2971-2978. ISSN 0019-9567 (doi:10.1128/IAI.00558-08)

Jecna, L., Svarovska, A., Besteiro, S., Mottram, J.C., Coombs, G.H., and Volf, P. (2009) Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis. Journal of Medical Entomology, 46 (3). pp. 605-609. ISSN 0022-2585 (doi:10.1603/033.046.0327)