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Moss, C. X., Brown, E., Hamilton, A., Van der Veken, P., Augustyns, K. and Mottram, J. (2015) An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei. PLoS ONE, 10(3), e0123241. (doi: 10.1371/journal.pone.0123241) (PMID:25816352) (PMCID:PMC4376731)

Porcel, B. M. et al. (2014) The streamlined genome of Phytomonas spp. Relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genetics, 10(2), e1004007. (doi: 10.1371/journal.pgen.1004007)

Cull, B., Prado Godinho, J. L., Fernandes Rodrigues, J. C., Frank, B., Schurigt, U., Williams, R. A.M., Coombs, G. H. and Mottram, J. C. (2014) Glycosome turnover in Leishmania major is mediated by autophagy. Autophagy, 10(12), pp. 2143-2157. (doi: 10.4161/auto.36438) (PMID:25484087)

Machado, M.K.M., Marcondes, M.F., Juliano, M.A., McLuskey, K., Mottram, J.C. , Moss, C.X., Juliano, L. and Oliveira, V. (2013) Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2. FEBS Journal, 280(11), pp. 2608-2621. (doi: 10.1111/febs.12248)

Williams, R.A.M., Mottram, J.C. and Coombs, G.H. (2013) Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major. Journal of Biological Chemistry, 288(5), pp. 3678-3690. (doi: 10.1074/jbc.M112.415372)

Fernandez, M. L. S., Engels, K. K., Bender, F., Gassel, M., Marhofer, R. J., Mottram, J. C. and Selzer, P. M. (2012) High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a. Microbiology, 158(9), pp. 2262-2271. (doi: 10.1099/mic.0.059428-0)

Morrison, L. S. et al. (2012) Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation. Cellular Microbiology, 14(8), pp. 1271-1286. (doi: 10.1111/j.1462-5822.2012.01798.x)

McLuskey, K., Rudolf, J., Proto, W. R., Isaacs, N. W., Coombs, G. H., Moss, C. X. and Mottram, J. C. (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences of the United States of America, 109(19), pp. 7469-7474. (doi: 10.1073/pnas.1200885109)

Williams, R. A. M., Smith, T. K., Cull, B., Mottram, J. C. and Coombs, G. H. (2012) ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. PLoS Pathogens, 8(5), e1002695. (doi: 10.1371/journal.ppat.1002695)

Castanys-Muñoz, E., Brown, E., Coombs, G.H. and Mottram, J.C. (2012) Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells. Cell Death and Disease, 3(9), e385. (doi: 10.1038/cddis.2012.113)

Proto, W. R., Castanys-Munoz, E., Black, A., Tetley, L., Moss, C. X., Juliano, L., Coombs, G. H. and Mottram, J. C. (2011) Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. Journal of Biological Chemistry, 286(46), pp. 39914-39925. (doi: 10.1074/jbc.M111.292334)

Ambit, A., Woods, K. L., Cull, B., Coombs, G. H. and Mottram, J. C. (2011) Morphological events during the cell cycle of Leishmania major. Eukaryotic Cell, 10(11), pp. 1429-1438. (doi: 10.1128/EC.05118-11)

Duszenko, M. et al. (2011) Autophagy in protists. Autophagy, 7(2), pp. 127-158. (doi: 10.4161/auto.7.2.13310)

Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

Steert, K. et al. (2010) α-Ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. ChemMedChem, 5(10), pp. 1734-1748. (doi: 10.1002/cmdc.201000265)

Engels, K., Beyer, C., Suárez Fernández, M. L., Bender, F., Gaßel, M., Unden, G., Marhöfer, R. J., Mottram, J. C. and Selzer, P. M. (2010) Inhibition of Eimeria tenella CDK-Related kinase 2: from target identification to lead compounds. ChemMedChem, 5(8), pp. 1259-1271. (doi: 10.1002/cmdc.201000157)

Berg, M. et al. (2010) Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorganic and Medicinal Chemistry Letters, 20(6), pp. 2001-2006. (doi: 10.1016/j.bmcl.2010.01.099)

El-Fadili, A.K., Zangger, H., Desponds, C., Gonzalez, I.J., Zalila, H., Schaff, C., Ives, A., Masina, S., Mottram, J.C. and Fasel, N. (2010) Cathepsin B-like and cell death in the unicellular human pathogen Leishmania. Cell Death and Disease, 1(e71), pp. 1-9. (doi: 10.1038/cddis.2010.51)

Bryson, K., Besteiro, S., McGachy, H. A., Coombs, G. H., Mottram, J. C. and Alexander, J. (2009) Overexpression of the natural inhibitor of cysteine peptidases, ICP, in Leishmania mexicana leads to reduced virulence and a Th1 response. Infection and Immunity, 77(7), pp. 2971-2978. (doi: 10.1128/IAI.00558-08) (PMID:19433541) (PMCID:PMC2708542)

Williams, R. A. M., Westrop, G. D. and Coombs, G. H. (2009) Two pathways for cysteine biosynthesis in Leishmania major. Biochemical Journal, 420(3), pp. 451-462. (doi: 10.1042/BJ20082441)

Jecna, L., Svarovska, A., Besteiro, S., Mottram, J. C. , Coombs, G. H. and Volf, P. (2009) Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis. Journal of Medical Entomology, 46(3), pp. 605-609. (doi: 10.1603/033.046.0327)

Richardson, J. M., Morrison, L. S., Bland, N. D., Bruce, S., Coombs, G. H., Mottram, J. C. and Walkinshaw, M. D. (2009) Structures of Leishmania major orthologues of macrophage migration inhibitory factor. Biochemical and Biophysical Research Communications, 380(3), pp. 442-448. (doi: 10.1016/j.bbrc.2009.01.030)

This list was generated on Thu Oct 21 20:11:53 2021 BST.