Browse by Research Project Code

Havekes, R. et al. (2012) Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory. Journal of Neuroscience, 32 (50). pp. 18137-18149. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.3612-12.2012)

Monterisi, S., Favia, M., Guerra, L., Cardone, R.A., Marzulli, D., Reshkin, S.J., Casavola, V., and Zaccolo, M. (2012) CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity. Journal of Cell Science, 125 (5). pp. 1106-1117. ISSN 0021-9533 (doi:10.1242/jcs.089086)

Anthony, D.F., Sin, Y.Y., Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G., Houslay, M.D., and Baillie, G.S. (2011) β Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31 (5). pp. 1066-1075. ISSN 0270-7306 (doi:10.1128/MCB.00883-10)

Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F., Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D., and Baillie, G.S. (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50 (5). pp. 872-883. ISSN 0022-2828 (doi:10.1016/j.yjmcc.2011.02.006)

Day, J.P. et al. (2011) Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4). Journal of Medicinal Chemistry, 54 (9). pp. 3331-3347. ISSN 0022-2623 (doi:10.1021/jm200070e)

MacKenzie, K.F., Wallace, D.A., Hill, E.V., Anthony, D.F., Henderson, D.J.P., Houslay, D.M., Arthur, J.S.C., Baillie, G.S., and Houslay, M.D. (2011) Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. Biochemical Journal, 435 (3). pp. 755-769. ISSN 0264-6021 (doi:10.1042/BJ20101184)

Edwards, H.V., Christian, F., and Baillie, G.S. (2011) cAMP: Novel concepts in compartmentalised signalling. Seminars in Cell and Developmental Biology . ISSN 1084-9521 (doi:10.1016/j.semcdb.2011.09.005)

Christian, F., Anthony, D.F., Vadrevu, S., Riddell, T., Day, J.P., McLeod, R., Adams, D.R., Baillie, G.S., and Houslay, M.D. (2010) p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cellular Signalling, 22 (10). pp. 1576-1596. ISSN 0898-6568 (doi:10.1016/j.cellsig.2010.06.003)

Vaasa, A., Lust, M., Terrin, A., Uri, A., and Zaccolo, M. (2010) Small-molecule FRET probes for protein kinase activity monitoring in living cells. Biochemical and Biophysical Research Communications, 397 (4). pp. 750-755. ISSN 0006-291X (doi:10.1016/j.bbrc.2010.06.026)

Li, X. et al. (2010) Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochemical Journal, 428 (1). pp. 55-65. ISSN 0264-6021 (doi:10.1042/BJ20091672)

Kelly, M.P. et al. (2010) Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 107 (18). pp. 8457-8462. ISSN 0027-8424 (doi:10.1073/pnas.1000730107)

Bjorgo, E., Solheim, S.A., Abrahamsen, H., Baillie, G., Brown, K.M., Berge, T., Okkenhaug, K., Houslay, M.D., and Tasken, K. (2010) Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase A signaling pathways at the level of a protein kinase B/β-Arrestin/cAMP phosphodiesterase 4 complex. Molecular and Cellular Biology, 30 (7). pp. 1660-1672. ISSN 0270-7306 (doi:10.1128/MCB.00696-09)

Xu, T. et al. (2010) Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Science Signaling, 3 (113). ra20. ISSN 1945-0877 (doi:10.1126/scisignal.2000517)

Kim, H. w., Ha, S. H., Lee, M. N., Huston, E., Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M.D., and Ryu, S. H. (2010) cAMP controls mTOR through regulation of the dynamic interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30 (22). pp. 5406-5420. ISSN 0270-7306 (doi:10.1128/MCB.00217-10)

Rampersad, S. N., Ovens, J. D., Huston, E., Umana, M. B., Wilson, L. S., Netherton, S. J., Lynch, M. J., Baillie, G.S., Houslay, M.D., and Maurice, D. H. (2010) Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability. Journal of Biological Chemistry, 285 (44). pp. 33614-33622. ISSN 0021-9258 (doi:10.1074/jbc.M110.140004)

Houslay, M.D. (2010) Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends in Biochemical Sciences, 35 (2). pp. 91-100. ISSN 0968-0004 (doi:10.1016/j.tibs.2009.09.007)

Kiely, P.A., Baillie, G.S., Barrett, R., Buckley, D.A., Adams, D.R., Houslay, M.D., and O'Connor, R. (2009) Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for IGF-I-mediated regulation of focal adhesion kinase (FAK). Journal of Biological Chemistry, 284 . pp. 20263-20274. ISSN 0021-9258 (doi:10.1074/jbc.M109.017640)

Terrenoire, C., Houslay, M.D., Baillie, G.S., and Kass, R.S. (2009) The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3. Journal of Biological Chemistry, 284 (14). pp. 9140-9146. ISSN 0021-9258 (doi:10.1074/jbc.M805366200)

Vecsey, C.G. et al. (2009) Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 461 (7267). pp. 1122-1125. ISSN 0028-0836 (doi:10.1038/nature08488)

Mackenzie, Kirsty F. et al. (2008) Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. Biochemical Journal, 411 (2). pp. 361-369. ISSN 0264-6021 (doi:10.1042/BJ20071251)

McCahill, A., Campbell, L., McSorley, T., Lynch, M.J., Li, X., Yan, C., Baillie, G.S., and Houslay, M.D. (2008) In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10). Cellular Signalling, 20 (11). pp. 2071-2083. ISSN 08986568 (doi:10.1016/j.cellsig.2008.07.017)

Meng, D., Lynch, M. J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M.D., and Baillie, G.S. (2008) MEK1 Binds Directly to  Arrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization. Journal of Biological Chemistry, 284 (17). pp. 11425-11435. ISSN 0021-9258 (doi:10.1074/jbc.M806395200)