Fischer, A., Illingworth, C. J.R. , Campbell, P. J. and Mustonen, V. (2013) EMu: probabilistic inference of mutational processes and their localization in the cancer genome. Genome Biology, 14(4), R39. (doi: 10.1186/gb-2013-14-4-r39) (PMID:23628380) (PMCID:PMC3663107)
Text
266877.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
The spectrum of mutations discovered in cancer genomes can be explained by the activity of a few elementary mutational processes. We present a novel probabilistic method, EMu, to infer the mutational signatures of these processes from a collection of sequenced tumors. EMu naturally incorporates the tumor-specific opportunity for different mutation types according to sequence composition. Applying EMu to breast cancer data, we derive detailed maps of the activity of each process, both genome-wide and within specific local regions of the genome. Our work provides new opportunities to study the mutational processes underlying cancer development. EMu is available at http://www.sanger.ac.uk/resources/software/emu/.
Item Type: | Articles |
---|---|
Additional Information: | We would like to acknowledge the Wellcome Trust for support under grant reference 098051. AF is supported by the German Research Foundation (DFG) under grant reference number FI 1882/1-1. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Illingworth, Dr Chris |
Authors: | Fischer, A., Illingworth, C. J.R., Campbell, P. J., and Mustonen, V. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Genome Biology |
Publisher: | BioMed Central |
ISSN: | 1474-760X |
ISSN (Online): | 1465-6906 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in Genome Biology, 14(4):R39 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record