Helminth extracellular vesicles: interactions with the host immune system

Drurey, C. and Maizels, R. M. (2021) Helminth extracellular vesicles: interactions with the host immune system. Molecular Immunology, 137, pp. 124-133. (doi: 10.1016/j.molimm.2021.06.017) (PMID:34246032)

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Abstract

As long-lived parasites, helminths depend upon immunomodulation of their hosts for survival. The release of excretory-secretory (ES) products, including proteins, lipids and RNAs is how successful host manipulation is achieved. It has recently been discovered that the ES products of helminths contain extracellular vesicles (EVs), with every species investigated found to secrete these lipid-bound structures. EVs are perfect for packaging and delivering immune modulators to target cell types. This review outlines the research carried out on helminth EVs and their constituents thus far, as well as their interaction with components of the mammalian immune system. We discuss how targeting EVs will aid treatment of helminth infection and consider how EVs and their immunomodulatory cargo could be used as therapeutics as we progress through this exciting era.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Drurey, Claire and Maizels, Professor Rick
Creator Roles:
Drurey, C.Conceptualization, Writing – original draft, Writing – review and editing
Maizels, R. M.Conceptualization, Writing – review and editing, Funding acquisition
Authors: Drurey, C., and Maizels, R. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Molecular Immunology
Publisher:Elsevier
ISSN:0161-5890
ISSN (Online):1872-9142
Published Online:07 July 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Molecular Immunology 137: 124-133
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173801Helminths and the Immune System: Regulation, Regulators and ImmunityRichard MaizelsWellcome Trust (WELLCOTR)106122/A/14/ZInstitute of Infection, Immunity & Inflammation
308411Molecular and Cellular Interactions in Helminth InfectionsRichard MaizelsWellcome Trust (WELLCOTR)219530/Z/19/ZIII - Parasitology
170547The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/ZRIII - Parasitology