González-Cabaleiro, R. , Martinez-Rabert, E. , Argiz, L., van Kessel, M. A.H.J. and Smith, C. J. (2021) A framework based on fundamental biochemical principles to engineer microbial community dynamics. Current Opinion in Biotechnology, 67, pp. 111-118. (doi: 10.1016/j.copbio.2021.01.001) (PMID:33540361)
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Abstract
Microbial communities are complex but there are basic principles we can apply to constrain the assumed stochasticity of their activity. By understanding the trade-offs behind the kinetic parameters that define microbial growth, we can explain how local interspecies dependencies arise and shape the emerging properties of a community. If we integrate these theoretical descriptions with experimental ‘omics’ data and bioenergetics analysis of specific environmental conditions, predictions on activity, assembly and spatial structure can be obtained reducing the a priori unpredictable complexity of microbial communities. This information can be used to define the appropriate selective pressures to engineer bioprocesses and propose new hypotheses which can drive experimental research to accelerate innovation in biotechnology.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Argiz, Lucia and Martínez-Rabert, Eloi and Smith, Professor Cindy and Gonzalez-Cabaleiro, Dr Rebeca |
| Authors: | González-Cabaleiro, R., Martinez-Rabert, E., Argiz, L., van Kessel, M. A.H.J., and Smith, C. J. |
| College/School: | College of Science and Engineering > School of Engineering > Infrastructure and Environment |
| Journal Name: | Current Opinion in Biotechnology |
| Publisher: | Elsevier |
| ISSN: | 0958-1669 |
| ISSN (Online): | 1879-0429 |
| Published Online: | 01 February 2021 |
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