Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of Hepatitis C Virus

Magri, A., Mokrane, O., Lauder, K., Patel, A. H. and Castagnolo, D. (2019) Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of Hepatitis C Virus. Bioorganic and Medicinal Chemistry Letters, 29(5), pp. 724-728. (doi: 10.1016/j.bmcl.2019.01.008) (PMID:30661824)

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Abstract

Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patel, Professor Arvind and Magri, Mr Andrea
Authors: Magri, A., Mokrane, O., Lauder, K., Patel, A. H., and Castagnolo, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Bioorganic and Medicinal Chemistry Letters
Publisher:Elsevier
ISSN:0960-894X
ISSN (Online):1464-3405
Published Online:11 January 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Bioorganic and Medicinal Chemistry Letters 29(5):724-728
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656491Basis of the host range and tissue tropism for hepatitis C virusArvind PatelMedical Research Council (MRC)MC_UU_12014/2MVLS III - CENTRE FOR VIRUS RESEARCH