A portable 3D printer system for the diagnosis and treatment of multidrug-resistant bacteria

Glatzel, S., Hezwani, M., Kitson, P. J., Gromski, P. S., Schürer, S. and Cronin, L. (2016) A portable 3D printer system for the diagnosis and treatment of multidrug-resistant bacteria. Chem, 1(3), pp. 494-504. (doi:10.1016/j.chempr.2016.08.008)

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Abstract

Summary: Multidrug-resistant bacteria are a major threat to human health, but broad-spectrum antibiotics are losing efficacy. There is a need to screen a given drug against a bacterial infection outside of the laboratory. To address this need, we have designed and built an inexpensive and easy-to-use 3D-printer-based system that allows easily readable quantitative tests for the performance of antibacterial drugs. The platform creates a sterile diagnostic device by using 3D printing, and the device is filled automatically with growth medium, and then antibiotics are sprayed onto the medium by ink-jet technology. The sample for testing can be introduced via a fluid port, and the printer hot bed is used to incubate the device, allowing operation in the field. Combining advantages from various established tests of antibacterial performance, this allows the comparison of a specific antibiotics and bacteria. Also, this system can create and test several antibiotic formulations for therapeutic use, and we demonstrate this potential by investigating a mixture of pathogens that are only killed by a mixture of drugs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gromski, Dr Piotr and Hezwani, Dr Mohammed and Cronin, Professor Leroy and Kitson, Dr Philip and Glatzel, Dr Stefan
Authors: Glatzel, S., Hezwani, M., Kitson, P. J., Gromski, P. S., Schürer, S., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chem
Publisher:Elsevier
ISSN:2451-9294
Published Online:08 September 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Chem 1(3):494-504
Publisher Policy:Reproduced under a creative commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
503291Molecular-Metal-Oxide-nanoelectronicS (M-MOS): Achieving the Molecular LimitLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/H024107/1CHEM - CHEMISTRY
562821Innovative Manufacturing Research Centre for Continuous Manufacturing and Crystallisation (CMAC)Leroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/I033459/1CHEM - CHEMISTRY
577391Programmable Molecular Metal Oxides (PMMOs) - From Fundamentals to ApplicationLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/J015156/1CHEM - CHEMISTRY