On the fly multi-modal observation of ligand synthesis and complexation of Cu complexes in flow with ‘benchtop’ NMR and mass spectrometry

Porwol, L., Henson, A. , Kitson, P. J., Long, D. L. and Cronin, L. (2016) On the fly multi-modal observation of ligand synthesis and complexation of Cu complexes in flow with ‘benchtop’ NMR and mass spectrometry. Inorganic Chemistry Frontiers, 3(7), pp. 919-923. (doi:10.1039/C6QI00079G)

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Abstract

Exploring complex chemical systems requires reproducible and controllable ways to access non-equilibrium conditions. Herein we present a programmable flow system that can do both ligand synthesis and complexation on the fly, and the conditions of the reaction can be monitored using two simultaneous techniques, namely NMR and mass spectrometry. By using this approach we monitored the formation of unknown complexes, followed by crystallization that resulted in the characterisation of their structures giving 5 new compounds (4 isolated and fully characterised) which can be formulated as: Cu2(L1)4(μ-CO3)](BF4)2 (2); [Cu3(L1)6(μ-CO3)](PF6)2(OH)2 (3) [Cu2(L2)2](BF4)2 (4) and [Cu(L2)2](BF4)2·CH3CN (5).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Long, Dr De Liang and Henson, Dr Alon and Cronin, Professor Leroy and Kitson, Dr Philip
Authors: Porwol, L., Henson, A., Kitson, P. J., Long, D. L., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Inorganic Chemistry Frontiers
Publisher:R.S.C. Publications
ISSN:2052-1553
ISSN (Online):2052-1553
Published Online:11 May 2016
Copyright Holders:Copyright © 2016 R.S.C. Publications
First Published:First published in Inorganic Chemistry Frontiers 3(7):919-923
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
577391Programmable Molecular Metal Oxides (PMMOs) - From Fundamentals to ApplicationLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/J015156/1CHEM - CHEMISTRY
646611Programmable 'Digital' Synthesis for Discovery and Scale-up of Molecules, Clusters and NanomaterialsLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/L023652/1CHEM - CHEMISTRY
562821Innovative Manufacturing Research Centre for Continuous Manufacturing and Crystallisation (CMAC)Leroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/I033459/1CHEM - CHEMISTRY
616021Energy and the Physical Sciences: Hydrogen Production using a Proton Electron BufferLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/K023004/1CHEM - CHEMISTRY
599451Microscale Chemically Reactive Electronic AgentsLeroy CroninEuropean Commission (EC)FP7 ICT MICRE318671CHEM - CHEMISTRY