Browse by Research Project Code

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Marsango, S., Ward, R. J., Alvarez-Curto, E. and Milligan, G. (2018) Muscarinic receptor oligomerization. Neuropharmacology, 136(Part C), pp. 401-410. (doi: 10.1016/j.neuropharm.2017.11.023) (PMID:29146505) (PMCID:PMC6078712)

Pediani, J. D. , Ward, R. J., Godin, A. G., Marsango, S. and Milligan, G. (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562) (PMID:27080256) (PMCID:PMC4933229)

Moreno, J. L. et al. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science Signaling, 9(410), ra5. (doi: 10.1126/scisignal.aab0467) (PMID:26758213) (PMCID:PMC4819166)

Marsango, S., Caltabiano, G., Pou, C., Varela Liste, M. J. and Milligan, G. (2015) Analysis of human dopamine D3 receptor quaternary structure. Journal of Biological Chemistry, 290, pp. 15146-15162. (doi: 10.1074/jbc.M114.630681) (PMID:25931118) (PMCID:PMC4463457)

Aslanoglou, D., Alvarez-Curto, E. , Marsango, S. and Milligan, G. (2015) Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers. Journal of Biological Chemistry, 290(23), pp. 14785-14796. (doi: 10.1074/jbc.M115.649079) (PMID:25918156) (PMCID:PMC4505543)

Ward, R. J., Pediani, J. D. , Godin, A. G. and Milligan, G. (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Journal of Biological Chemistry, 290(20), pp. 12844-12857. (doi: 10.1074/jbc.M115.644724) (PMID:25825490) (PMCID:PMC4432300)

Marsango, S., Varela, M. J. and Milligan, G. (2015) Approaches to characterize and quantify oligomerization of GPCRs. In: Filizola, M. (ed.) G Protein-Coupled Receptors in Drug Discovery. Series: Methods in Molecular Biology, 1335 (1335). Springer New York, pp. 95-105. ISBN 9781493929139 (doi: 10.1007/978-1-4939-2914-6_7)

Ferre, S., Casado, V., Devi, L. A., Filizola, M., Jockers, R., Lohse, M. J., Milligan, G. , Pin, J.-P. and Guitart, X. (2014) G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacological Reviews, 66(2), pp. 413-434. (doi: 10.1124/pr.113.008052)

Milligan, G. (2013) The prevalence, maintenance, and relevance of G protein-coupled receptor oligomerization. Molecular Pharmacology, 84(1), pp. 158-169. (doi: 10.1124/mol.113.084780)

Patowary, S., Alvarez-Curto, E. , Xu, T.-R., Holz, J.D., Oliver, J.A., Milligan, G. and Raicu, V. (2013) The muscarinic M3acetylcholine receptor exists as two differently sized complexes at the plasma membrane. Biochemical Journal, 452(2), pp. 303-312. (doi: 10.1042/BJ20121902) (PMID:23521066)

Cunningham, M. R., McIntosh, K. A., Pediani, J. D. , Robben, J., Cooke, A. E., Nilsson, M., Gould, G. W. , Mundell, S., Milligan, G. and Plevin, R. (2012) Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4). Journal of Biological Chemistry, 287(20), pp. 16656-16669. (doi: 10.1074/jbc.M111.315911)

Xu, T.-R., Ward, R. J., Pediani, J. D. and Milligan, G. (2012) Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Journal of Biological Chemistry, 287, pp. 14937-14949. (doi: 10.1074/jbc.M111.334300)

Alvarez-Curto, E. , Prihandoko, R., Tautermann, C. S., Zwier, J. M., Pediani, J. D. , Lohse, M. J., Hoffmann, C., Tobin, A. B. and Milligan, G. (2011) Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a Receptor Activated Solely by Synthetic Ligand (RASSL). Molecular Pharmacology, 80(6), pp. 1033-1046. (doi: 10.1124/mol.111.074674) (PMID:21880827) (PMCID:PMC3228535)

Ward, R. J., Pediani, J. D. and Milligan, G. (2011) Heteromultimerization of cannabinoid CB1 receptor and orexin OX1 receptor generates a unique complex in which both protomers are regulated by orexin A. Journal of Biological Chemistry, 286(43), pp. 37414-37428. (doi: 10.1074/jbc.M111.287649)

Xu, T.‑R., Ward, R. J., Pediani, J. D. and Milligan, G. (2011) The orexin OX1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. Biochemical Journal, 439(1), pp. 171-183. (doi: 10.1042/BJ20110230)

Van Lith, M., Tiwari, S., Pediani, J. , Milligan, G. and Bulleid, N. J. (2011) Real-time monitoring of redox changes in the mammalian endoplasmic reticulum. Journal of Cell Science, 124(14), pp. 2349-2356. (doi: 10.1242/jcs.085530)

Ward, R. J., Pediani, J. D. and Milligan, G. (2011) Ligand-induced internalisation of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging. British Journal of Pharmacology, 162(6), pp. 1439-1452. (doi: 10.1111/j.1476-5381.2010.01156.x)

Saenz del Burgo, L. and Milligan, G. (2011) Ligand regulation of GPCR quaternary structure. In: Giraldo, J. and Pin, J.-P. (eds.) G Protein-Coupled Receptors: From Structure to Function G Protein-Coupled Receptors: From Structure to Function. Series: RSC drug discovery (8). RSC Publishing: Cambridge, UK, pp. 111-152. ISBN 9781849733441 (doi: 10.1039/9781849733441-00111)

Smith, N. J. and Milligan, G. (2010) Allostery at G protein-coupled receptor Homo- and Heteromers: uncharted pharmacological landscapes. Pharmacological Reviews, 62(4), pp. 701-725. (doi: 10.1124/pr.110.002667) (PMID:21079041) (PMCID:PMC2993260)

Alvarez-Curto, E. , Pediani, J. D. and Milligan, G. (2010) Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors. Analytical and Bioanalytical Chemistry, 398(1), pp. 167-180. (doi: 10.1007/s00216-010-3823-4) (PMID:20517598)

Alvarez-Curto, E., Ward, R. J., Pediani, J. D. and Milligan, G. (2010) Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET. Journal of Biological Chemistry, 285(30), pp. 23318-23330. (doi: 10.1074/jbc.M110.122184) (PMID:20489201) (PMCID:PMC2906324)

del Burgo, L. S. and Milligan, G. (2010) Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening. Expert Opinion on Drug Discovery, 5(5), pp. 461-474. (doi: 10.1517/17460441003720467) (PMID:22823130)

Milligan, G. (2010) The role of dimerisation in the cellular trafficking of G-protein-coupled receptors. Current Opinion in Pharmacology, 10(1), pp. 23-29. (doi: 10.1016/j.coph.2009.09.010) (PMID:19850521)

This list was generated on Fri Sep 29 02:24:37 2023 BST.