Electrochemical reduction of nitrobenzene via redox-mediated chronoamperometry

Stergiou, A. D., Broadhurst, D. H. and Symes, M. D. (2022) Electrochemical reduction of nitrobenzene via redox-mediated chronoamperometry. STAR Protocols, 3(4), 101817. (doi: 10.1016/j.xpro.2022.101817)

Abstract

Anilines are important feedstocks for pharmaceuticals, dyes, and other materials, but traditional approaches to their syntheses usually lack selectivity and environmental sustainability. Here, we describe the selective reduction of nitrobenzene to aniline under mild conditions, using water as the ultimate source of the required protons and electrons. We describe the electrochemical cell assembly, and detail steps for electrochemical reduction followed by organic extraction and analysis of the extracts using NMR.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Symes, Professor Mark and Stergiou, Mr Athanasios and Broadhurst, Mr Daniel
• Authors: Stergiou, A. D., Broadhurst, D. H., and Symes, M. D.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: STAR Protocols
• Publisher: Cell Press
• ISSN: 2666-1667
• ISSN (Online): 2666-1667
• Published Online: 04 November 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in STAR Protocols 3(4): 101817
• Publisher Policy: Reproduced under a Creative Commons License
• Data DOI: 10.5525/gla.researchdata.1279

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
190559		Upgrading the small scale equipment base for early career researchers in the engineering and physical sciences	Miles Padgett	Engineering and Physical Sciences Research Council (EPSRC)	EP/K031732/1	P&S - Physics & Astronomy
301241		Ultra-Reduced Polyoxometalates as Electron-Coupled-Proton-Systems for Energy Storage	Leroy Cronin	Engineering and Physical Sciences Research Council (EPSRC)	EP/R020914/1	Chemistry