Extra-nodal subcutaneous Hodgkin's-like lymphoma and subsequent regression in a cat

Newton, J. A., de Vicente, F., Haugland, S. P., Scase, T. J. and Helm, J. (2014) Extra-nodal subcutaneous Hodgkin's-like lymphoma and subsequent regression in a cat. Journal of Feline Medicine and Surgery, 17(6), pp. 543-547. (doi: 10.1177/1098612X14541262)

Abstract

Hodgkin’s like lymphoma is a slow growing neoplasm, usually affecting the lymph nodes of the head and neck, which has been sporadically described in veterinary patients. This report describes the clinical and histopathological features in a 9-year-old male neutered Siamese cat that presented with a 6 week history of mid-dorso cranium swelling. Immunohistochemistry demonstrated positive staining for CD79a, paired box protein and B lymphocyte antigen-36, with variable, weak-to-moderate cytoplasmic staining for human leukocyte antigen-DR and CD18, and negative staining for antimacrophage antibody. The diagnosis based on incisional biopsy was Hodgkin’s-like lymphoma; however, no evidence of neoplasia was found following wide surgical excision. This case report demonstrates two unreported items of note: the novel extranodal site of Hodgkin’s-like lymphoma in a cat and tumour regression following initial biopsy. It is hypothesised that the surgical trauma of biopsying the lesion or the introduction of foreign material may have caused the regression of the neoplastic cells through induction of an anti-tumour immune or inflammatory response.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Scase, Dr Timothy and Helm, Miss Jenny
• Authors: Newton, J. A., de Vicente, F., Haugland, S. P., Scase, T. J., and Helm, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Feline Medicine and Surgery
• Publisher: Sage
• ISSN: 1098-612X
• ISSN (Online): 1532-2750