Winder, S.J., Jess, T. and Ayscough, K.R. (2003) SCP1 encodes an actin-bundling protein in yeast. Biochemical Journal, 375, pp. 287-295.
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Abstract
The association of F-actin (filamentous actin) with a large number of binding proteins is essential for cellular function. Actin-binding proteins control the dynamics of actin filaments, nucleate new filaments and facilitate formation of higher-order structures such as actin bundles. The yeast gene SCP1 encodes a small protein with aignificant homology to mammalian SM22/transgelin. We have investigated the role of Scp1p in budding yeast to probe the fundamental role of this family of proteins. Here, we demonstrate that Scp1p binds to F-actin and induces the formation oftight F-actin bundles in vitro.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Winder, S.J., Jess, T., and Ayscough, K.R. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Biochemical Journal |
| Publisher: | Portland Press Ltd. |
| ISSN: | 0264-6021 |
| ISSN (Online): | 1470-8728 |
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