Bacterial secreted effectors and caspase-3 interactions

Wall, D. M. and McCormick, B. A. (2014) Bacterial secreted effectors and caspase-3 interactions. Cellular Microbiology, 16(12), pp. 1746-1756. (doi: 10.1111/cmi.12368) (PMID:25262664) (PMCID:PMC4257569)

Abstract

Apoptosis is a critical process that intrinsically links organism survival to its ability to induce controlled death. Thus, functional apoptosis allows organisms to remove perceived threats to their survival by targeting those cells that it determines pose a direct risk. Central to this process are apoptotic caspases, enzymes that form a signalling cascade, converting danger signals via initiator caspases into activation of the executioner caspase, caspase-3. This enzyme begins disassembly of the cell by activating DNA degrading enzymes and degrading the cellular architecture. Interaction of pathogenic bacteria with caspases, and in particular, caspase-3, can therefore impact both host cell and bacterial survival. With roles outside cell death such as cell differentiation, control of signalling pathways and immunomodulation also being described for caspase-3, bacterial interactions with caspase-3 may be of far more significance in infection than previously recognized. In this review, we highlight the ways in which bacterial pathogens have evolved to subvert caspase-3 both through effector proteins that directly interact with the enzyme or by modulating pathways that influence its activation and activity.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Wall, Dr Daniel
• Authors: Wall, D. M., and McCormick, B. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Cellular Microbiology
• Publisher: Wiley-Blackwell Publishing
• ISSN: 1462-5814
• ISSN (Online): 1462-5822
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in Cellular Microbiology 16(12):1746-1756
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
60784	1	Survival and dissemination of enteric pathogens through exploitation and inhibition of programmed cell death pathways in circulating immune cells.	Daniel Wall	Biotechnology and Biological Sciences Research Council (BBSRC)	BB/K008005/1	III - BACTERIOLOGY