Quantification of ion binding using electrospray mass spectrometry

Mathieson, J. S., Cooper, G. J.T. , Symes, M. and Cronin, L. (2014) Quantification of ion binding using electrospray mass spectrometry. Inorganic Chemistry Frontiers, 1, pp. 49-52. (doi: 10.1039/C3QI00037K)

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Mass spectrometry has predominately been used as a qualitative tool in the analysis of complexes with quantitative studies being difficult to validate. Here, we present a method where electrospray mass spectrometry is used to give both a qualitative and quantitative measure of ion binding with cross validation by solution 1H NMR, demonstrating it is possible to utilize gas-phase electrospray mass spectrometry continuous variation data to deduce binding stoichiometries in solutions where artifacts and nonspecific complexes are also observed.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Symes, Professor Mark and Mathieson, Dr Jennifer and Cooper, Dr Geoff and Cronin, Professor Lee
Authors: Mathieson, J. S., Cooper, G. J.T., Symes, M., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Inorganic Chemistry Frontiers
Publisher:R S C Publications
ISSN (Online):2052-1553

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