Quantification of ion binding using electrospray mass spectrometry

Mathieson, J. S., Cooper, G. J.T. , Symes, M. and Cronin, L. (2014) Quantification of ion binding using electrospray mass spectrometry. Inorganic Chemistry Frontiers, 1, pp. 49-52. (doi: 10.1039/C3QI00037K)

Abstract

Mass spectrometry has predominately been used as a qualitative tool in the analysis of complexes with quantitative studies being difficult to validate. Here, we present a method where electrospray mass spectrometry is used to give both a qualitative and quantitative measure of ion binding with cross validation by solution 1H NMR, demonstrating it is possible to utilize gas-phase electrospray mass spectrometry continuous variation data to deduce binding stoichiometries in solutions where artifacts and nonspecific complexes are also observed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Symes, Professor Mark and Mathieson, Dr Jennifer and Cooper, Dr Geoff and Cronin, Professor Lee
• Authors: Mathieson, J. S., Cooper, G. J.T., Symes, M., and Cronin, L.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Inorganic Chemistry Frontiers
• Publisher: R S C Publications
• ISSN: 2052-1553
• ISSN (Online): 2052-1553