Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J. and Selman, C. (2014) Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell, 13(5), pp. 962-964. (doi: 10.1111/acel.12255) (PMID:25059507) (PMCID:PMC4331740)
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Abstract
Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms. The precise mechanism underlying the effects of the IIS on lifespan and health is currently unclear, although cellular stress resistance may be important. We have previously demonstrated that mice globally lacking insulin receptor substrate 1 (Irs1−/−) are long-lived and enjoy a greater period of their life free from age-related pathology compared with wild-type (WT) controls. In this study, we show that primary dermal fibroblasts and primary myoblasts derived from Irs1−/− mice are no more resistant to a range of oxidant and nonoxidant chemical stressors than cells derived from WT mice.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Selman, Professor Colin and Sinclair, Miss Amy |
| Authors: | Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J., and Selman, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Aging Cell |
| Publisher: | Anatomical Society and John Wiley & Sons Ltd. |
| ISSN: | 1474-9718 |
| ISSN (Online): | 1474-9726 |
| Copyright Holders: | Copyright © 2014 The Authors |
| First Published: | First published in Aging Cell 13(5):962-964 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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