Combining a targeted radiotherapy and gene therapy approach for adenocarcinoma of prostate

Fullerton, N.E., Boyd, M., Mairs, R.J. , Keith, W.N. , Alderwish, O., Brown, M.M., Livingstone, A. and Kirk, D. (2004) Combining a targeted radiotherapy and gene therapy approach for adenocarcinoma of prostate. Prostate Cancer and Prostatic Diseases, 7(4), pp. 355-363. (doi: 10.1038/sj.pcan.4500760)

Abstract

A targeted radiotherapy/gene therapy approach for prostate cancer, using the radiopharmaceutical [¹³¹1]meta- iodobenzylguanidine ([¹³¹1]MIBG), would restrict the effects of radiotherapy to malignant cells, thereby increasing efficacy and decreasing morbidity of radiotherapy. Prostate cancer cells were transfected with a transgene encoding the noradrenaline transporter (NAT) under the control of tumour-specific telomerase promoters, enabling them to actively take up [¹³¹1]MIBG. This led to tumour-specific cell kill. This strategy has the advantage of generating a radiological bystander effect, leading to the destruction of neighbouring tumour cells that have escaped transfection. This targeted approach could be a promising tumour-specific treatment option for prostate cancer.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Keith, Professor Nicol and Mairs, Professor Robert and Boyd, Dr Marie
• Authors: Fullerton, N.E., Boyd, M., Mairs, R.J., Keith, W.N., Alderwish, O., Brown, M.M., Livingstone, A., and Kirk, D.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer); Q Science > QH Natural history > QH426 Genetics
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Prostate Cancer and Prostatic Diseases
• ISSN: 1365-7852