From screen to target: insights and approaches for the development of anti-virulence compounds

Beckham, K. S.H. and Roe, A. J. (2014) From screen to target: insights and approaches for the development of anti-virulence compounds. Frontiers in Cellular and Infection Microbiology, 4(139), (doi: 10.3389/fcimb.2014.00139)

Abstract

A detailed understanding of host-pathogen interactions provides exciting opportunities to interfere with the infection process. Anti-virulence compounds aim to modulate or pacify pathogenesis by reducing expression of critical virulence determinants. In particular, prevention of attachment by inhibiting adhesion mechanisms has been the subject of intense research. Whilst it has proven relatively straightforward to develop robust screens for potential anti-virulence compounds, understanding their precise mode of action has proven much more challenging. In this review we illustrate this challenge from our own experiences working with the salicylidene acylhydrazide group of compounds. We aim to provide a useful perspective to guide researchers interested in this field and to avoid some of the obvious pitfalls.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roe, Professor Andrew
• Authors: Beckham, K. S.H., and Roe, A. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Frontiers in Cellular and Infection Microbiology
• Publisher: Frontiers Research Foundation
• ISSN: 2235-2988
• ISSN (Online): 2235-2988
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in Frontiers in Cellular and Infection Microbiology 4(139)
• Publisher Policy: Reproduced under a Creative Commons License