Coates, L. C. et al. (2014) Development and testing of new candidate psoriatic arthritis screening questionnaires combining optimal questions from existing tools. Arthritis Care and Research, 66(9), pp. 1410-1416. (doi: 10.1002/acr.22284)
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Abstract
Objective: Several questionnaires have been developed to screen for psoriatic arthritis (PsA), but head-to-head studies have found limitations. This study aimed to develop new questionnaires encompassing the most discriminative questions from existing instruments.<p></p> Methods: Data from the CONTEST study, a head-to-head comparison of 3 existing questionnaires, were used to identify items with a Youden index score of ≥0.1. These were combined using 4 approaches: CONTEST (simple additions of questions), CONTESTw (weighting using logistic regression), CONTESTjt (addition of a joint manikin), and CONTESTtree (additional questions identified by classification and regression tree [CART] analysis). These candidate questionnaires were tested in independent data sets.<p></p> Results: Twelve individual questions with a Youden index score of ≥0.1 were identified, but 4 of these were excluded due to duplication and redundancy. Weighting for 2 of these questions was included in CONTESTw. Receiver operating characteristic (ROC) curve analysis showed that involvement in 6 joint areas on the manikin was predictive of PsA for inclusion in CONTESTjt. CART analysis identified a further 5 questions for inclusion in CONTESTtree. CONTESTtree was not significant on ROC curve analysis and discarded. The other 3 questionnaires were significant in all data sets, although CONTESTw was slightly inferior to the others in the validation data sets. Potential cut points for referral were also discussed.<p></p> Conclusion: Of 4 candidate questionnaires combining existing discriminatory items to identify PsA in people with psoriasis, 3 were found to be significant on ROC curve analysis. Testing in independent data sets identified 2 questionnaires (CONTEST and CONTESTjt) that should be pursued for further prospective testing.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Burden, Professor David and Wilson, Dr Hilary |
Authors: | Coates, L. C., Walsh, J., Haroon, M., FitzGerald, O., Aslam, T., Al Balushi, F., Burden, A.D., Burden-Teh, E., Caperon, A. R., Cerio, R., Chattopadhyay, C., Chinoy, H., Goodfield, M. J.D., Kay, L., Kelly, S., Kirkham, B. W., Lovell, C. R., Marzo-Ortega, H., McHugh, N., Murphy, R., Reynolds, N. J., Smith, C. H., Stewart, E. J.C., Warren, R. B., Waxman, R., Wilson, H. E., and Helliwell, P. S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Arthritis Care and Research |
Publisher: | John Wiley & Sons, Inc. |
ISSN: | 2151-464X |
ISSN (Online): | 2151-4658 |
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