Loading dose ibandronate versus standard oral ibandronate in patients with bone metastases from breast cancer

Macpherson, I.R., Bray, C.A., Hopkins, C., Hannon, R.A., Lewsley, L.A., Ritchie, D.M. and Canney, P. (2014) Loading dose ibandronate versus standard oral ibandronate in patients with bone metastases from breast cancer. Clinical Breast Cancer, 15(2), pp. 117-127. (doi: 10.1016/j.clbc.2014.09.009) (PMID:25454689)

Abstract

Purpose<p></p> This phase II trial evaluated the efficacy and safety of loading-dose I.V. ibandronate in patients with breast cancer with bone metastases.<p></p> Patients and methods<p></p> 34 patients were randomised to receive a loading-dose of 12 mg I.V. ibandronate on day 1 then oral ibandronate 50mgs daily (Arm A), or standard oral therapy of 50mgs ibandronate daily from day 1 (Arm B). The primary end-point was percentage change in serum CTX from baseline by day 5 on study. Secondary / exploratory end-points included percentage change in other bone turnover markers (NTX, PINP, bone ALP) and change in average bone pain score.<p></p> Results<p></p> There was a significantly greater reduction in serum CTX at day 5 in Arm A compared with Arm B (median difference 15.82%, p=0.005). There was also a significantly greater reduction in urine NTX/Cr at day 5 (p=0.009) and at the end of weeks 1-8 (averaged) (p=0.006). Average bone pain score was lower in Arm A at the end of 8 weeks (p=0.012). There were no additional adverse events following administration of 12mg I.V. loading dose of ibandronate.<p></p> Conclusion<p></p> A 12 mg dose of I.V. ibandronate rapidly reduces markers of bone turnover and can be administered without additional toxicity.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Evans, Mrs Carol and Lewsley, Ms Liz-Anne and Kelly, Mrs Caroline and MacPherson, Professor Iain
• Authors: Macpherson, I.R., Bray, C.A., Hopkins, C., Hannon, R.A., Lewsley, L.A., Ritchie, D.M., and Canney, P.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer); R Medicine > RM Therapeutics. Pharmacology
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Clinical Breast Cancer
• Publisher: Elsevier
• ISSN: 1526-8209
• ISSN (Online): 1938-0666