Ward, S. J., Douce, G. , Dougan, G. and Wren, B. W. (1997) Delivery of non-toxic fragments of Clostridium difficile toxin A to the mucosal immune system. Reviews in Medical Microbiology, 8(Sup 1), S34-S36. (doi: 10.1097/00013542-199712001-00016)
Full text not currently available from Enlighten.
Abstract
Polymerase chain reaction fragments coding for 8, 14, 20 and 36 C-terminal repeats from Clostridium difficile toxin A were expressed as fusions to fragment C of tetanus toxin. These fusions were expressed within a rationally attenuated Salmonella typhimurium htrA mutant which has been shown to be effective at delivering heterologous antigens to the gastro-intestinal mucosa. The larger fragments retained their receptor-binding properties, and the construct containing 14 repeats induced an antitoxin A serum response within mice.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Douce, Dr Gillian |
| Authors: | Ward, S. J., Douce, G., Dougan, G., and Wren, B. W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Reviews in Medical Microbiology |
| Publisher: | Lippincott Williams & Wilkins |
| ISSN: | 0954-139X |
| ISSN (Online): | 1473-5601 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details