Genetic detoxification of bacterial toxins: a new approach to vaccine development

Rappuoli, R., Douce, G. , Dougan, G. and Pizza, M. (1995) Genetic detoxification of bacterial toxins: a new approach to vaccine development. International Archives of Allergy and Immunology, 108(4), pp. 327-33. (doi: 10.1159/000237176)

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Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of immunogens with unique properties, some of which may be used for innovative approaches to vaccination.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Douce, Dr Gillian
Authors: Rappuoli, R., Douce, G., Dougan, G., and Pizza, M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:International Archives of Allergy and Immunology
ISSN (Online):1423-0097
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