Survival in solid cancer patients following intensive care unit admission

Puxty, K. , McLoone, P. , Quasim, T. , Kinsella, J. and Morrison, D. (2014) Survival in solid cancer patients following intensive care unit admission. Intensive Care Medicine, 14(10), pp. 1409-1428. (doi: 10.1007/s00134-014-3471-9)

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Purpose: One in seven patients admitted to intensive care units (ICU) has a cancer diagnosis but evidence on their expected outcomes after admission has not been synthesised.<p></p> Methods: Systematic literature review of solid cancer adult patients admitted to ICU from 2000 onwards using EMBASE and MEDLINE electronic databases.<p></p> Results: There were 48 papers identified that reported survival in ICU patients with solid cancers. ICU mortality was reported in 35 studies comprising a total sample of 25,339 patients and ranging from 4.5 to 85 %. The average mortality of the distribution of reported mortality rates within ICU was 31.2 % (95 % CI 24.0–39.0 %). Hospital mortality was reported in 31 studies across a total sample of 74,061 patients. The average hospital mortality was 38.2 % (33.8–42.7 %) and ranged from 4.6 to 76.8 %. Poorer physiological score, invasive mechanical ventilation and poor functional status were associated with higher mortality.<p></p> Conclusions: Several factors have been associated with poor survival in ICU cancer patients; however, primary research is still needed to describe outcomes in cancer patients with sufficient case mix and treatment details to be of prognostic value to clinicians.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McLoone, Mr Philip and Morrison, Dr David and Quasim, Professor Tara and Kinsella, Professor John and Puxty, Dr Kathryn
Authors: Puxty, K., McLoone, P., Quasim, T., Kinsella, J., and Morrison, D.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Intensive Care Medicine
Publisher:Springer Berlin Heidelberg
ISSN (Online):1432-1238

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