Bryant, D. M. and Stow, J. L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)
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Abstract
One way of controlling the activity of E-cadherin--a protein that is, simultaneously, a major cell-adhesion molecule, a powerful tumour suppressor, a determinant of cell polarity and a partner to the potent catenin signalling molecules--is to keep it on the move. During the past two decades, many insights into the fundamental role of E-cadherin in these processes have been garnered. Studies during the past five years have begun to reveal the importance of intracellular trafficking as a means of regulating the functions of E-cadherin. E-cadherin is trafficked to and from the cell surface by exocytic and multiple endocytic pathways. In this article, we survey the vesicle-trafficking machinery that is responsible for the sorting, transport, actin association and vesicle targeting of E-cadherin to regulate its movement and function during growth and development and, possibly, in cancer.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Bryant, Dr David |
Authors: | Bryant, D. M., and Stow, J. L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Trends in Cell Biology |
Publisher: | Elsevier Ltd. |
ISSN: | 0962-8924 |
ISSN (Online): | 1879-3088 |
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