Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, J. et al. (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44(9), pp. 669-674. (doi:10.1016/j.ijpara.2014.05.001)

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Abstract

ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coltherd, Dr Jennifer and Harnett, Professor Margaret and Al-Riyami, Dr Lamyaa and Tay, Dr Hwee Kee and Rzepecka, Dr Justyna and Khalaf, Dr Abedawn and Suckling, Professor Colin
Authors: Rzepecka, J., Coates, M. L., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J. K., Janicova, L., Khalaf, A. I., Siebeke, I., Suckling, C. J., Harnett, M. M., and Harnett, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Science and Engineering > School of Chemistry
Journal Name:International Journal for Parasitology
Publisher:Elsevier Ltd.
ISSN:0020-7519
ISSN (Online):1879-0135
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in International Journal for Parasitology 44(9):669-674
Publisher Policy:Reproduced under a Creative Commons License

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