The cat, the fly and the beetle - why genetics needs a semantic education

Padmanabhan, S. , Hastie, C. , Sainsbury, C., McBride, M. W. , Connell, J. M. and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi: 10.1142/S1793351X09000665)

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Major advances have been made in the understanding of the genetic basis of diseases since Mendel's publication of the results of plant breeding experiments in 1866. To date these advances have been largely confined to the monogenic disorders — caused by mutations in a single gene. The public-health implications of these advances is relatively limited. In this review we explore our current understanding of the genetic basis of human traits and the reasons why current theories may account for the difficulties in identifying the genes for common diseases. We then postulate that semantic computing may be rightly poised to help understand complex disease causation, and explore the efforts that have been made to date to develop the necessary technological approach to the problem.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hastie, Dr Claire and Sainsbury, Dr Christoper and McBride, Dr Martin and Connell, Professor John and Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna
Authors: Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F.
Subjects:Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:International Journal of Semantic Computing
Publisher:World Scientific Publishing
ISSN (Online):1793-7108

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