Barry, G. et al. (2014) NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery. Journal of General Virology, 95(Pt. 8), pp. 1640-1646. (doi: 10.1099/vir.0.065425-0)
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Abstract
Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ratinier, Dr Maxime and Palmarini, Professor Massimo and Blomstrom, Dr Anne-Lie and Caporale, Dr Marco and Schnettler, Dr Esther and Kohl, Professor Alain and Barry, Dr Gerald and Varela, Dr Mariana |
Authors: | Barry, G., Varela, M., Ratinier, M., Blomstrom, A.-L., Caporale, M., Seehusen, F., Hahn, K., Schnettler, E., Baumgartner, W., Kohl, A., and Palmarini, M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of General Virology |
Publisher: | Society for General Microbiology |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
Copyright Holders: | Copyright © 2014 The Authors |
First Published: | First published in Journal of General Virology 95(Pt.8):1640-1646 |
Publisher Policy: | Reproduced under a Creative Commons License |
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