The pathogenesis of visna, a lentivirus induced immunopathologic disease of the central nervous system

Kennedy, P. G. E., Narayan, O., Zink, M. C., Hess, J., Clements, J. and Adams, R. J. (1989) The pathogenesis of visna, a lentivirus induced immunopathologic disease of the central nervous system. In: Gilden, D. H. and Lipton, H. L. (eds.) Clinical and Molecular Aspects of Neurotropic Virus Infection. Series: Developments in medical virology (5). Kluwer Academic Publishers, pp. 393-421. ISBN 9781461289357 (doi: 10.1007/978-1-4613-1675-6_15)

Abstract

The slowly progressive paralytic disease of sheep, visna, represents the culmination of a complex series of host-virus interactions involving genetic susceptibility of selective populations of cells to infection, limited but continuous expression of viral proteins by antigen-presenting cells and an exuberant cellular immune response that ultimately causes widespread destruction of the neuropil. Much of the information on the pathogenesis of these lesions comes from experimental intracerebral inoculation of sheep with visna virus. However, in this chapter we have addressed the topic from the standpoint of a natural infection which leads to systemic disease and later neurological complications. By combining studies on virus replication in cultured host cells of the same type as those infected in the animal, with studies on cells obtained from naturally and experimentally-infected sheep, we have reconstructed events in the natural infection, tracing the course of the virus as it progresses from non-neural tissues to the central nervous system. Guided by the experimental data, we have formulated a possible virus-induced, immunopathologic basis for disease.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Kennedy, Professor Peter
• Authors: Kennedy, P. G. E., Narayan, O., Zink, M. C., Hess, J., Clements, J., and Adams, R. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Publisher: Kluwer Academic Publishers
• ISBN: 9781461289357