Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses

Marrero, H., Astion, M. L., Coles, J. A. and Orkand, R. K. (1989) Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses. Nature, 339(6223), pp. 378-380. (doi: 10.1038/339378a0)

Abstract

The functions of glial cells in the nervous system are not well defined, with the exception of myelin production by oligoden-drocytes1, uptake of amino-acid synaptic transmitters2, and a contribution to extracellular potassium homeostasis3–5. Neuroglia have receptors for neurotransmitters6,7 which may be involved in neuron-glia interactions. Recent studies have demonstrated voltage-gated ion channels in glial membranes8–12. In a study of the optic nerve of the frog, small areas of the surface were examined with the loose patch-clamp method13,14, and voltage-gated Na+ and K+ channels, presumably located in the membranes of the astrocytes forming the glia limitans, were identified15,16. We now report that nerve impulses in the axons of the frog optic nerve transiently alter the properties of the voltage-dependent membrane channels of the surface glial cells (astrocytes), a demonstration of a new form of neuron-glia interaction.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coles, Dr Jonathan
• Authors: Marrero, H., Astion, M. L., Coles, J. A., and Orkand, R. K.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Nature
• Publisher: Nature Publishing Group
• ISSN: 0028-0836
• ISSN (Online): 1476-4687