Adjunctive use of ezogabine/retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: evaluation of efficacy and tolerability

Brodie, M. J., French, J. A., McDonald, S. A., Lee, W.-J., Adams, B., Scott, A., Nohria, V. and DeRossett, S. (2014) Adjunctive use of ezogabine/retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: evaluation of efficacy and tolerability. Epilepsy Research, 108(5), pp. 989-994. (doi: 10.1016/j.eplepsyres.2014.03.008)

Abstract

Integrated data from three double-blind, randomized, placebo-controlled trials were analyzed to evaluate the efficacy and tolerability of ezogabine (EZG; US adopted name)/retigabine (RTG; international non-proprietary name) when used in combination with ≥1 sodium channel blocking antiepileptic drug (AED), ≥1 non-sodium channel blocking AED, or ≥1 AED from both the sodium channel and non-sodium channel mechanistic groups. Efficacy and tolerability appeared to be similar across all three groups of patients.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Brodie, Professor Martin
• Authors: Brodie, M. J., French, J. A., McDonald, S. A., Lee, W.-J., Adams, B., Scott, A., Nohria, V., and DeRossett, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Epilepsy Research
• Publisher: Elsevier B.V.
• ISSN: 0920-1211
• ISSN (Online): 1872-6844