In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries

Brown, E. M., Latimer, C., Allsopp, P., Ternan, N. G., McMullan, G., McDougall, G. J., Stewart, D., Crozier, A., Rowland, I. and Gill, C. I. R. (2014) In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries. Journal of Agricultural and Food Chemistry, 62(18), pp. 3852-3866. (doi: 10.1021/jf4050759)

Abstract

The etiology of colorectal cancer (CRC), a common cause of cancer-related mortality globally, has strong associations with diet. There is considerable epidemiological evidence that fruits and vegetables are associated with reduced risk of CRC. This paper reviews the extensive evidence, both from in vitro studies and animal models, that components of berry fruits can modulate biomarkers of DNA damage and that these effects may be potentially chemoprotective, given the likely role that oxidative damage plays in mutation rate and cancer risk. Human intervention trials with berries are generally consistent in indicating a capacity to significantly decrease oxidative damage to DNA, but represent limited evidence for anticarcinogenicity, relying as they do on surrogate risk markers. To understand the effects of berry consumption on colorectal cancer risk, future studies will need to be well controlled, with defined berry extracts, using suitable and clinically relevant end points and considering the importance of the gut microbiota.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crozier, Professor Alan
• Authors: Brown, E. M., Latimer, C., Allsopp, P., Ternan, N. G., McMullan, G., McDougall, G. J., Stewart, D., Crozier, A., Rowland, I., and Gill, C. I. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Agricultural and Food Chemistry
• Journal Abbr.: J. Agric. Food Chem.
• Publisher: American Chemical Society
• ISSN: 0021-8561
• ISSN (Online): 1520-5118