Nematode Hsp90: highly conserved but functionally diverse

Gillan, V. and Devaney, E. (2014) Nematode Hsp90: highly conserved but functionally diverse. Parasitology, 141(9), pp. 1-13. (doi: 10.1017/S0031182014000304) (PMID:24721950)

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Nematodes are amongst the most successful and abundant organisms on the planet with approximately 30 000 species described, although the actual number of species is estimated to be one million or more. Despite sharing a relatively simple and invariant body plan, there is considerable diversity within the phylum. Nematodes have evolved to colonize most ecological niches, and can be free-living or can parasitize plants or animals to the detriment of the host organism. In this review we consider the role of heat shock protein 90 (Hsp90) in the nematode life cycle. We describe studies on Hsp90 in the free-living nematode Caenorhabditis elegans and comparative work on the parasitic species Brugia pahangi, and consider whether a dependence upon Hsp90 can be exploited for the control of parasitic species.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and Gillan, Dr Victoria
Authors: Gillan, V., and Devaney, E.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN (Online):1469-8161
Copyright Holders:Copyright © 2014 Cambridge University Press
First Published:First published in Parasitology 141(9):1-13
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
398951Hsp90 as a molecular target in lymphatic filariasisEileen DevaneyWellcome Trust (WELLCOME)076734/Z/05/ZIII - PARASITOLOGY
441591A comparative analysis of Hsp90 its possible role in drug resistance in nematode parasitesEileen DevaneyBiotechnology and Biological Sciences Research Council (BBSRC)BB/E013473/1III - PARASITOLOGY