Gillan, V. and Devaney, E. (2014) Nematode Hsp90: highly conserved but functionally diverse. Parasitology, 141(9), pp. 1-13. (doi: 10.1017/S0031182014000304) (PMID:24721950)
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Abstract
Nematodes are amongst the most successful and abundant organisms on the planet with approximately 30 000 species described, although the actual number of species is estimated to be one million or more. Despite sharing a relatively simple and invariant body plan, there is considerable diversity within the phylum. Nematodes have evolved to colonize most ecological niches, and can be free-living or can parasitize plants or animals to the detriment of the host organism. In this review we consider the role of heat shock protein 90 (Hsp90) in the nematode life cycle. We describe studies on Hsp90 in the free-living nematode Caenorhabditis elegans and comparative work on the parasitic species Brugia pahangi, and consider whether a dependence upon Hsp90 can be exploited for the control of parasitic species.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Devaney, Professor Eileen and Gillan, Dr Victoria |
| Authors: | Gillan, V., and Devaney, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Parasitology |
| Publisher: | Cambridge University Press |
| ISSN: | 0031-1820 |
| ISSN (Online): | 1469-8161 |
| Copyright Holders: | Copyright © 2014 Cambridge University Press |
| First Published: | First published in Parasitology 141(9):1-13 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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