Shanks, E. J. (2014) Strategic siRNA screening approaches to target cancer at the Cancer Research UK Beatson Institute. Combinatorial Chemistry and High Throughput Screening, 17(4), pp. 328-332. (doi: 10.2174/1386207317666140323133249)
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Abstract
The RNAi Screening Facility at the Cancer Research UK Beatson Institute combines siRNA genome-wide screening with drug screening coupled with High Content Imaging and fluorescence-based phenotypic assays to target multiple types of cancer. Here, we describe the infrastructure of the Facility and the approaches we utilise. We also share our experiences in running such a facility and developing and executing screening campaigns, with particular regard to high content multiparametric analysis, data management and statistical analysis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Shanks, Dr Emma |
| Authors: | Shanks, E. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Combinatorial Chemistry and High Throughput Screening |
| Publisher: | Bentham Science Publishers Ltd. |
| ISSN: | 1386-2073 |
| ISSN (Online): | 1875-5402 |
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